Combined analysis of minimal residual disease at two time points and its value for risk stratification in childhood B-lineage acute lymphoblastic leukemia
The study was aimed to explore the value of minimal residual disease (MRD) for risk stratification in childhood precursor-B-acute lymphoblastic leukemia. MRD was monitored at two time points (TP1, after induction and TP2, before consolidation therapy) by quantitative detection of monoclonal immunoglobulin heavy chain gene rearrangements. This study stratified 105 patients into three MRD risk groups: standard-risk, MRD < 10(-4) at both TP1 and TP2; high-risk, TP1 >= 10(-2) or TP2 >= 10(-3); and others were classified as intermediate-risk. We incorporated this MRD risk information to refine risk stratification among these patients and developed a new classification system that predicted the treatment outcomes more successfully than did the traditional risk classification criteria. (C) 2009 Elsevier Ltd. All rights reserved.
基金：
Beijing Municipal Science Technology [D0905001040431]; National Key Technologies Research & Development Program of the 11th 5-Year Plan [2007BAI04B03]; Beijing Novel ProgramBeijing Municipal Science & Technology Commission [2005B06]
第一作者机构：[1]Capital Med Univ, Beijing Childrens Hosp, Hematol Ctr, Beijing 100045, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Childrens Hosp, Hematol Ctr, Beijing 100045, Peoples R China;[3]Capital Med Univ, Beijing Childrens Hosp, Hematol Ctr, 56 Nanlishi Rd, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Cui Lei,Li Zhigang,Wu Minyuan,et al.Combined analysis of minimal residual disease at two time points and its value for risk stratification in childhood B-lineage acute lymphoblastic leukemia[J].LEUKEMIA RESEARCH.2010,34(10):1314-1319.doi:10.1016/j.leukres.2009.11.031.
APA：
Cui, Lei,Li, Zhigang,Wu, Minyuan,Li, Weijing,Gao, Chao&Deng, Guoren.(2010).Combined analysis of minimal residual disease at two time points and its value for risk stratification in childhood B-lineage acute lymphoblastic leukemia.LEUKEMIA RESEARCH,34,(10)
MLA：
Cui, Lei,et al."Combined analysis of minimal residual disease at two time points and its value for risk stratification in childhood B-lineage acute lymphoblastic leukemia".LEUKEMIA RESEARCH 34..10(2010):1314-1319
