The prevalence of plasmid-mediated quinolone resistance determinants among clinical isolates of ESBL or AmpC-producing Escherichia coli from Chinese pediatric patients
Three kinds of PMQR determinants (qnr genes, aac(6')-Ib-cr, and qepA) have been discovered and shown to be widely distributed among clinical isolates. To characterize the prevalence of PMQR determinants in ESBL or AmpC-producing E. coli clinical isolates in Chinese children, a total of 292 ESBL or AmpC-producing E. coli clinical isolates collected from five children's hospitals in China from 2005 to 2006 were screened for PMQR determinants by PCR. Twenty (6.8%) of the 292 isolates were positive for PMQR determinants. A total of 12 (4.1%) isolates were positive for qnr genes, comprising three positive for qnrA (1.0%), three for qnrB (1.0%), and six for qnrS (2.1%). Twenty-four (8.2%) isolates were positive for aac(6')-Ib, of which 10 (3.4% of 292) had the -cr variant. There was no qepA gene detected in the isolates. Conjugation revealed that qnr, aac(6')-Ib-cr, and ESBL-encoding genes were transferred together.
第一作者机构：[1]Capital Med Univ, Beijing Childrens Hosp, Beijing 100045, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Childrens Hosp, Beijing 100045, Peoples R China;[7]Capital Med Univ, Beijing Childrens Hosp, 56 S Lishi Rd, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Han Chenxi,Yang Yonghong,Wang Minggui,et al.The prevalence of plasmid-mediated quinolone resistance determinants among clinical isolates of ESBL or AmpC-producing Escherichia coli from Chinese pediatric patients[J].MICROBIOLOGY AND IMMUNOLOGY.2010,54(3):123-128.doi:10.1111/j.1348-0421.2010.00200.x.
APA：
Han, Chenxi,Yang, Yonghong,Wang, Minggui,Wang, Aihua,Lu, Quan...&Shen, Xuzhuang.(2010).The prevalence of plasmid-mediated quinolone resistance determinants among clinical isolates of ESBL or AmpC-producing Escherichia coli from Chinese pediatric patients.MICROBIOLOGY AND IMMUNOLOGY,54,(3)
MLA：
Han, Chenxi,et al."The prevalence of plasmid-mediated quinolone resistance determinants among clinical isolates of ESBL or AmpC-producing Escherichia coli from Chinese pediatric patients".MICROBIOLOGY AND IMMUNOLOGY 54..3(2010):123-128
