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Impact of Platinum on the Whole Mitochondrial Genome of Ovarian Carcinomas Both In Vivo and In Vitro

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收录情况： ◇ SCIE

作者：

机构： [1]Chinese Acad Med Sci, Dept Obstet & Gynecol, Peking Union Med Coll Hosp, Beijing 100037, Peoples R China; [2]Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China

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关键词： Mitochondrial DNA Somatic mutation Polymorphism Drug-resistant

摘要：

Objectives: To investigate somatic mitochondrial DNA mutation in primary and recurrent ovarian carcinoma tissues as well as that in drug-resistant cell lines to illuminate the impact of chemotherapeutic drugs on mitochondrial DNA (mtDNA). Methods: Complete mtDNA genomes of 20 pairs of ovarian carcinomas and their matched normal tissues together with 2 ovarian carcinoma cell lines and their 4 platinum-resistant cell lines were sequenced. Mitochondrial DNA alterations, consequent amino acid alterations were compared between the 2 groups of patients and the 2 types of cell lines. Results: A large number of mtDNA new polymorphisms (55) and mutations (18) were identified in 20 ovarian carcinoma samples. Platinum-based chemotherapy did not increase the number of new polymorphisms (P = 0.094), mutations (P = 0.688), and consequent amino acid alterations (P = 0.202 and 0.795). Data gained from the cell lines also indicated that platinum had some effect on the mitochondrial genome but not specific to particular positions. Conclusions: What we found suggested that mtDNA damage could be made by chemotherapeutic drugs but not as much as imagined in ovarian carcinomas. Some of the mtDNA defects might be part of the disease processes and cell properties as well as a consequence of treatment.

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中科院(CAS)分区：

出版当年[2008]版：

大类 | 4 区医学

小类 | 3 区妇产科学 4 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区妇产科学 3 区肿瘤学

JCR分区：

出版当年[2007]版：

Q3 OBSTETRICS & GYNECOLOGY Q4 ONCOLOGY

最新[2023]版：

Q1 OBSTETRICS & GYNECOLOGY Q1 ONCOLOGY Q2 ONCOLOGY

影响因子： 4.5 最新[2023版] 3.9 最新五年平均 1.425 出版当年[2007版] 1.548 出版当年五年平均 1.469 出版前一年[2006版] 1.932 出版后一年[2008版]

第一作者：

第一作者机构： [1]Chinese Acad Med Sci, Dept Obstet & Gynecol, Peking Union Med Coll Hosp, Beijing 100037, Peoples R China;

通讯作者：

通讯机构： [1]Chinese Acad Med Sci, Dept Obstet & Gynecol, Peking Union Med Coll Hosp, Beijing 100037, Peoples R China;

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