Background: Giant and large intracranial aneurysms represent enormous therapeutic challenges for neurosurgeons as well as for endovascular therapists. Since they may involve entire vessels or be irregular in shape, the rate of complete obliteration with GDCs is low and the incidence of recanalization is very high. So the technique of stent-assisted coil placement is designed to treat aneurysms. Objective: This study was to evaluate the endovascular treatment of giant and large intracranial aneurysms using neuroform stent-assisted coil placement. Methods: Thirty-six patients harboring giant or large intracranial aneurysms were treated by using the neuroform stent-assisted coil placement. It was parallel to navigate the neuroform stent and the microcatheter. Results: Thirty-five of neuroform stents were easily delivered and deployed at the desired location. Of the 35 aneurysms successfully stented, all the aneurysms were occluded with stent-assisted coiling. Twenty-nine were totally occluded, and six aneurysms were with neck remnants. There was no complication related to the procedure except for the asymptomatic migration of the stents in two cases. All the patients recovered well. Conclusion: The neuroform stent-assisted coil placement may be a favorable technique for treatment of giant and large intracranial aneurysms. Further study is necessary to assess the long-term outcome.