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Viral etiology of acute childhood encephalitis in Beijing diagnosed by analysis of single samples

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机构: [1]SWEDISH INST INFECT DIS CONTROL,DEPT VIROL,STOCKHOLM,SWEDEN; [2]BEIJING CHILDRENS HOSP,VIROL LAB,56 NAN LISHI RD,BEIJING 100045,PEOPLES R CHINA
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关键词: acute childhood encephalitis viral etiology polymerase chain reaction Beijing China

摘要:
Objective. To understand the viral etiology of acute childhood encephalitis in Beijing. Methods. Ninety seven Chinese children (between 7 months and 13 years of age) with acute encephalitis were retrospectively investigated. They were treated in Beijing Children's Hospital between June, 1991, and October, 1994. Different serologic methods (immunofluorescence assay, enzyme-linked immunosorbent assay, solid phase reverse immunosorbent test) were used for detection of IgM antibody to enteroviruses, herpesviruses, mumps, measles, rubella and Japanese encephalitis virus. The viral DNA of six herpesviruses was detected by polymerase chain reaction. Results, Viral etiology was identified in 35 of 97 (36.0%) cases. The most frequently identified pathogens were enteroviruses (15; 15.4%), followed by mumps (7; 7.2%), rubella (6; 6.1%), Japanese encephalitis virus (5; 5.1%), human herpesvirus 6 (2; 2.0%), herpes simplex virus (2; 2.0%) and Epstein-Barr virus (1; 1.0%). IgM antibody in cerebrospinal fluid was detected for enterovirus, mumps and rubella viruses. Conclusions. Enteroviruses were the most frequent viral pathogens of acute childhood encephalitis in Beijing. Detection of IgM in cerebrospinal fluid may be useful for diagnosis in certain cases of viral encephalitis.

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出版当年[1995]版:
最新[2023]版:
大类 | 4 区 医学
小类 | 3 区 儿科 4 区 免疫学 4 区 传染病学
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出版当年[1994]版:
最新[2023]版:
Q1 PEDIATRICS Q2 INFECTIOUS DISEASES Q3 IMMUNOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[1994版] 出版当年五年平均 出版前一年[1993版]

第一作者:
第一作者机构: [1]SWEDISH INST INFECT DIS CONTROL,DEPT VIROL,STOCKHOLM,SWEDEN; [2]BEIJING CHILDRENS HOSP,VIROL LAB,56 NAN LISHI RD,BEIJING 100045,PEOPLES R CHINA
通讯作者:
通讯机构: [1]SWEDISH INST INFECT DIS CONTROL,DEPT VIROL,STOCKHOLM,SWEDEN; [2]BEIJING CHILDRENS HOSP,VIROL LAB,56 NAN LISHI RD,BEIJING 100045,PEOPLES R CHINA
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