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EFFECT OF MEXILETINE ON ENERGY-METABOLISM OF ISCHEMIC BRAIN IN MICE

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收录情况： ◇ SCIE

作者：

机构： [1]BEIJING NEUROSURG INST,BEIJING 100050,PEOPLES R CHINA

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关键词： MEXILETINE CEREBRAL ISCHEMIA ADENOSINE TRIPHOSPHATE PHOSPHOCREATINE LACTATES

摘要：

After 30 s ischemia induced by decapitation, the contents of ATP and phosphocreatine (PC) in mouse brain reduced, while that of lactic acid (LA) increased. When mexiletine (3.1-50 mg . kg-1) was injected ip 30 min before decapitation, the brain ATP and PC reduction, and LA accumulation were both alleviated in a dose-dependent manner. These findings suggested that mexiletine was effective in ameliorating the energy exhaustion in the ischemic brain.

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出版当年[1991]版：

无

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区药学 2 区化学：综合

JCR分区：

出版当年[1990]版：

无

最新[2023]版：

Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 PHARMACOLOGY & PHARMACY

影响因子： 6.9 最新[2023版] 7.6 最新五年平均 0 出版当年[1990版] 0 出版当年五年平均 0 出版前一年[1989版]

第一作者：

第一作者机构： [1]BEIJING NEUROSURG INST,BEIJING 100050,PEOPLES R CHINA

通讯作者：

通讯机构： [1]BEIJING NEUROSURG INST,BEIJING 100050,PEOPLES R CHINA

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