机构：[1]Department of Dermatology, Beijing Children’ s Hospital, Capital Medical University, National Center for Children’ s Health, Beijing 100045, China.临床科室职能科室临床流行病与循证医学中心皮肤科首都医科大学附属北京儿童医院[2]Department of Dermatovenereology, Maanshan people’ s hospital, Maanshan 243000, China.
Background The term vascular anomalies include various vascular tumors and vascular malformations, among them infantile hemangiomas and capillary malformations are the most well-known associated diseases in early ages. Multiple drugs have been introduced for intervention, but susceptibility test in vitro were scarcely reported. Objective To evaluate the inhibition effect of different drugs by adenosine triphosphate sensitivity assay in vitro before the treatment of infantile hemangiomas and capillary malformations. Methods Specimens were selected from 5 cases of infantile hemangiomas and 11 cases of capillary malformations. Propranolol, rapamycin, sildenafil and itraconazole were tested for their growth inhibition effect by using the adenosine triphosphate sensitivity assay. Results Propranolol demonstrated inhibitory effects on infantile hemangiomas cells. Rapamycin and itraconazole both showed inhibitory effects on infantile hemangiomas cells and capillary malformations cells. Sildenafil has no growth inhibitory effect on infantile hemangiomas cells or capillary malformations cells. Conclusion Adenosine triphosphate sensitivity assay is a sensitive and useful testing method before the management of vascular anomalies, and individualized medication suggestions for the choice of therapeutic drugs were offered based on the testing result and together with a comprehensive evaluation of each infant.
基金：
Capital Health Research and Development of Special [2016-2-2093]; Beijing Municipal Administration of Hospitals Incubating Program [PX2016014]; Beijing Children's Hospital Clinic-Scientific Young Investigator Program [BCHYIPB-2016-02]
第一作者机构：[1]Department of Dermatology, Beijing Children’ s Hospital, Capital Medical University, National Center for Children’ s Health, Beijing 100045, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Dermatology, Beijing Children’ s Hospital, Capital Medical University, National Center for Children’ s Health, Beijing 100045, China.[*1]Department of Dermatology, Beijing Children’ s Hospital, Capital Medical University, National Center for Children’ s Health, Beijing, 100045, China
推荐引用方式(GB/T 7714)：
Li Li,Bin Yang,Li Wei,et al.Application of the adenosine triphosphate sensitivity assay in infantile vascular anomalies[J].BMC PEDIATRICS.2020,20(1):-.doi:10.1186/s12887-020-1974-9.
APA：
Li Li,Bin Yang,Li Wei,Bin Zhang,Xiao-feng Han...&Lin Ma.(2020).Application of the adenosine triphosphate sensitivity assay in infantile vascular anomalies.BMC PEDIATRICS,20,(1)
MLA：
Li Li,et al."Application of the adenosine triphosphate sensitivity assay in infantile vascular anomalies".BMC PEDIATRICS 20..1(2020):-
