机构：[1]State Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China,[2]Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China,医技科室(本部)放射科（本部）北京朝阳医院[3]Department of Radiology, Anzhen Hospital, Capital Medical University, Beijing, China,医技科室医学影像科首都医科大学附属安贞医院[4]Beijing Key Lab of MRI and Brain Informatics, Beijing, China,科技平台磁共振成像脑信息学北京市重点实验室首都医科大学宣武医院[5]School of Psychology, Capital Normal University, Beijing, China,[6]Department of Psychology, University of the Chinese Academy of Sciences, Beijing, China
Background: Mild cognitive impairment (MCI) frequently occurs in Parkinson's disease (PD). Neurovascular changes interact with neurodegenerative processes in PD. However, the deficits of cerebral blood flow (CBF) perfusion and the associated functional connectivity (FC) in PD patients with MCI (PD-MCI) remain unclear. Purpose: This study aimed to explore the specific neurovascular perfusion alterations in PD-MCI compared to PD with normal cognition (PD-NC) and healthy controls (HCs), and to further examine the resultant whole brain FC changes in the abnormal perfusion regions. Methods: Relative CBF (rCBF) was calculated using arterial spin labeling (ASL) in 54 patients with PD (27 patients with PD-NC and 27 patients with PD-MCI) and 25 HCs matched for age and gender ratio, who also underwent the structural MRI, resting-state functional MRI (rs-fMRI) and neuropsychological examinations. The gray matter (GM) changes in PD patients were analyzed using voxel-based morphometry (VBM). The alterations in rCBF perfusion and FC among groups were then analyzed respectively. Additionally, correlations between these alterations and neuropsychological performances were further examined. Results: Compared to HC, left caudate atrophy was detected in patients with PD. In comparison to both PD-NC and HC, patients with PD-MCI specifically exhibited hypoperfusion in the parietal memory network (PMN) in the precuneus (PCu) and decreased PCu-FC in the right striatum. Moreover, PCu perfusion and PCu-FC strengths in the right striatum were positively associated with memory performance in PD-MCI. Conclusions: These findings suggest that the posterior PMN dysfunction underlies memory deficits in PD-MCI.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [61473196, 61621136008, 61672065]; Beijing Talents Foundation [2016000021223TD07]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2015M570165]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding [ZYLX201609]; Key Projects in the National Science and Technology Pillar Program [2012BAI10B04]
第一作者机构：[1]State Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China,[2]Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China,
通讯作者：
通讯机构：[1]State Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China,[5]School of Psychology, Capital Normal University, Beijing, China,[6]Department of Psychology, University of the Chinese Academy of Sciences, Beijing, China
推荐引用方式(GB/T 7714)：
Xiuqin Jia,Ying Li,Kuncheng Li,et al.Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment[J].FRONTIERS IN AGING NEUROSCIENCE.2019,10:doi:10.3389/fnagi.2018.00427.
APA：
Xiuqin Jia,Ying Li,Kuncheng Li,Peipeng Liang&Xiaolan Fu.(2019).Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment.FRONTIERS IN AGING NEUROSCIENCE,10,
MLA：
Xiuqin Jia,et al."Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment".FRONTIERS IN AGING NEUROSCIENCE 10.(2019)
