机构：[1]Department of Oral Medicine, Peking University School of Stomatology, Beijing, China,[2]National Center of Gerontology, Beijing Hospital, Beijing, China,[3]Beijing Anzhen Hospital, Capital Medical University, Beijing, China首都医科大学附属安贞医院
Background: Photodynamic therapy (PDT) has demonstrated promising results in the treatment of oral leukoplakia. This study evaluated the clinical efficacy and side effects of PDT in the treatment of Chinese patients with oral leukoplakia. Methods: Twenty-nine patients with oral leukoplakia were enrolled in this study, including patients with both homogenous and non-homogenous lesions and various dysplastic tissues. All patients received PDT using a 632 nm laser at 500 mW/cm(2) power density at a dosage of 90-180 J/cm(2) and with aminolevulinic acid (ALA) used as a photosensitizer. A fixing and restricting complex as well as high laser power density for PDT in oral cavity was applied. Results: An overall response rate of 86.2% was achieved in this study, including 55.2% complete remission and 31.0% partial remission. The only adverse events observed in subjects were transient local ulcer and pain. It is observed the PDT utilizing ALA showed strong effectiveness in patients with moderate to severe dysplasia, as less treatment time per cm(2) of lesion is required. Conclusion: Topic ALA-PDT is effective to treat oral leukoplakia, especially for that with the presence of dysplasia. A fixing and restricting complex as well as high laser power density for PDT in oral cavity should be considered as an optimal choice.
基金：
Non-profit Industry Research Specific Fund of National Health and Family Planning Commission of China [201502018]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81771071]; Program for New Clinical Techniques and Therapies of Peking University School and Hospital of Stomatology [PKUSSNCT-16A07]; Program of Peking University School and Hospital of Stomatology [PKUSS20170103]
第一作者机构：[1]Department of Oral Medicine, Peking University School of Stomatology, Beijing, China,
通讯作者：
通讯机构：[1]Department of Oral Medicine, Peking University School of Stomatology, Beijing, China,
推荐引用方式(GB/T 7714)：
Ying Han,Si Xu,Jianqiu Jin,et al.Primary Clinical Evaluation of Photodynamic Therapy With Ora Leukoplakia in Chinese Patients[J].FRONTIERS IN PHYSIOLOGY.2019,9(JAN):-.doi:10.3389/fphys.2018.01911.
APA：
Ying Han,Si Xu,Jianqiu Jin,Xing Wang,Xiaodan Liu...&Hongwei Liu.(2019).Primary Clinical Evaluation of Photodynamic Therapy With Ora Leukoplakia in Chinese Patients.FRONTIERS IN PHYSIOLOGY,9,(JAN)
MLA：
Ying Han,et al."Primary Clinical Evaluation of Photodynamic Therapy With Ora Leukoplakia in Chinese Patients".FRONTIERS IN PHYSIOLOGY 9..JAN(2019):-
