机构：[a]Beijing Anzhen Hospital, Capital Medical University - Beijing Institute of Heart, Lung and Blood Vessel Diseases, 100029, China首都医科大学附属安贞医院[b]Department of Atherosclerosis, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China临床科室动脉硬化门诊首都医科大学附属安贞医院[c]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China临床科室心脏内科中心首都医科大学附属安贞医院[d]Department of Echo Cardiography, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China医技科室超声心动科首都医科大学附属安贞医院[e]Department of Cardiology, Tianjin Chest Hospital, Tianjin, 300051, China
Homozygous familial hypercholesterolemia developed into severe cardiovascular consequences early. Untreated HoFH usually cannot survive over 30 years old. Acute coronary syndrome(ACS) caused by plaque rupture is one of the main causes of death in HoFH. As the highest resolution intravascular imaging technique, optical coherence tomography(OCT) can clearly show the thickness and structural characteristics of atherosclerotic plaque caps. In this study, a Chinese male HoFH received percutaneous coronary intervention for unstable angina. After analyzed his genetic and follow-up data, OCT was performed during interventional therapy. Multiple lipid rich plaques accompanied with inflammatory cell infiltration and a thin-cap fibroatheroma(TCFA) were noted, which reflected the vulnerability of plaques. The utility of OCT had certain guiding significance for strategy of interventional therapy and the long-term drug management. And this case suggested that it was important to undergo OCT examination for patients with HoFH who required percutaneous coronary intervention. (c) 2019 Published by Elsevier B.V.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81370443, 81170793]
第一作者机构：[a]Beijing Anzhen Hospital, Capital Medical University - Beijing Institute of Heart, Lung and Blood Vessel Diseases, 100029, China[c]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China
共同第一作者：
通讯作者：
通讯机构：[a]Beijing Anzhen Hospital, Capital Medical University - Beijing Institute of Heart, Lung and Blood Vessel Diseases, 100029, China[b]Department of Atherosclerosis, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China[c]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China[*1]2 Anzhen Road, Chaoyang District, Beijing, 100029, China.[*2]2 Anzhen Road, Chaoyang District, Beijing, 100029, China.
推荐引用方式(GB/T 7714)：
Zesen Liu,Jie Peng,Shilong Wang,et al.Percutaneous coronary intervention for a Chinese familial hypercholesterolemia homozygous under the guidance of optical coherence tomography[J].ATHEROSCLEROSIS SUPPLEMENTS.2019,36:19-23.doi:10.1016/j.atherosclerosissup.2019.01.004.
APA：
Zesen Liu,Jie Peng,Shilong Wang,Tao Jiang,Weicong Zhang...&Jie Lin.(2019).Percutaneous coronary intervention for a Chinese familial hypercholesterolemia homozygous under the guidance of optical coherence tomography.ATHEROSCLEROSIS SUPPLEMENTS,36,
MLA：
Zesen Liu,et al."Percutaneous coronary intervention for a Chinese familial hypercholesterolemia homozygous under the guidance of optical coherence tomography".ATHEROSCLEROSIS SUPPLEMENTS 36.(2019):19-23
