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Increased Peripheral CD137 Expression in a Mouse Model of Permanent Focal Cerebral Ischemia

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China [2]Department of Neurology, Peking University People’s Hospital, Beijing 100044, China

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关键词： CD137 CD137L MCAO Cerebral ischemia

摘要：

Various studies demonstrate that CD137 (TNFRSF9, 4-1BB) promotes atherosclerosis and vascular inflammation in experimental models via interactions with the CD137 ligand (CD137L). However, the exact role of CD137 in ischemic stroke remains unclear. In this study, we analyzed dynamic changes of peripheral CD137 expression on T cells in a mouse model of cerebral ischemia-middle cerebral artery occlusion (MCAO), as well as alternation of neurological function, infarct size and cerebral inflammatory status after inhibition of the CD137/CD137L pathway using an anti-CD137L monoclonal antibody. MCAO mice showed elevated surface expression of CD137 on T cells in both peripheral blood and lymphoid tissues during early cerebral ischemia. Remarkably, blockade of the CD137/CD137L pathway reduced the post-ischemic brain damage. Our findings indicate that enhanced CD137 costimulation occurs in early cerebral ischemia and promotes T cell activation, which in turn upregulates inflammatory immune response and possibly exerting deleterious effects on cerebral ischemia.

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中科院(CAS)分区：

出版当年[2018]版：

大类 | 3 区医学

小类 | 3 区神经科学 4 区细胞生物学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区细胞生物学 4 区神经科学

JCR分区：

出版当年[2017]版：

Q2 CELL BIOLOGY Q2 NEUROSCIENCES

最新[2023]版：

Q2 NEUROSCIENCES Q3 CELL BIOLOGY

影响因子： 3.6 最新[2023版] 4.2 最新五年平均 3.895 出版当年[2017版] 2.992 出版当年五年平均 2.939 出版前一年[2016版] 3.811 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China

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通讯作者：

通讯机构： [1]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China

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