机构：[1]Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.临床科室心脏外科中心首都医科大学附属安贞医院[2]Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.首都医科大学附属安贞医院[3]Beijing Lab for Cardiovascular Precision Medicine, Beijing, China.[4]Beijing Engineering Research Center of Vascular Prostheses, Beijing, China.
The effect of temperature on cerebral injury during hypothermic circulatory arrest (HCA) has never been specifically studied. This study aimed to compare the effects of two different temperatures used for HCA on the degree of brain injury in pig models. Thirteen pigs were randomly assigned to a deep hypothermic circulatory arrest (DHCA) group (n = 5), moderate hypothermic circulatory arrest (MHCA) group (n = 5), or control group (n = 3). No significant differences in immunohistochemical assay results, including Bax, Bcl-2, and Caspase 3 staining, and a TUNEL assay, were observed between the DHCA and MHCA groups. Furthermore, no significant difference was found for biomarkers of brain injury (Soluble protein-100B) between the two experimental groups. Similarly, no significant difference was observed in the trend of changes in inflammatory factors, including tumor necrosis factor-α, interleukin (IL)-2, and IL-6, between the two groups (p > 0.05). However, coagulation factors, including FXI and FVII, were different between the DHCA and MHCA groups (p < 0.05). Therefore, it can be concluded that MHCA does not increase the risk of cerebral injury. Considering the adverse effects of DHCA on the coagulation system, MHCA is more suitable for current clinical practice.
基金：
National Science Foundation of ChinaNational Natural Science Foundation of China [81600362]; Beijing Municipal Administration of Hospitals' Youth Programme [QML20170602]; Capital Health Research and Development of Special [2018-2-2-66]
第一作者机构：[1]Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.[2]Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.[3]Beijing Lab for Cardiovascular Precision Medicine, Beijing, China.[4]Beijing Engineering Research Center of Vascular Prostheses, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.[2]Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.[3]Beijing Lab for Cardiovascular Precision Medicine, Beijing, China.[4]Beijing Engineering Research Center of Vascular Prostheses, Beijing, China.[*1]Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Street, Chaoyang District, Beijing 100029, China[*2]Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Street, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Ming Gong,Lei Li,Yang Liu,et al.Moderate Hypothermic Circulatory Arrest Is Preferable During Cardiopulmonary Bypass.[J].Therapeutic hypothermia and temperature management.2019,-.doi:10.1089/ther.2019.0005.
APA：
Ming Gong,Lei Li,Yang Liu,Shijun Xu,Lu Dai...&Hongjia Zhang.(2019).Moderate Hypothermic Circulatory Arrest Is Preferable During Cardiopulmonary Bypass..Therapeutic hypothermia and temperature management,,
MLA：
Ming Gong,et al."Moderate Hypothermic Circulatory Arrest Is Preferable During Cardiopulmonary Bypass.".Therapeutic hypothermia and temperature management .(2019):-
