Haematocrit differences modify the association of cardiopulmonary bypass reoxygenation with acute kidney injury after paediatric Tetralogy of Fallot repair.
机构：[1]Graduate School, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China[2]Department of Cardiovascular Surgery and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China临床科室心脏外科中心血管科首都医科大学附属安贞医院[3]Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Little is known regarding the potential impact of haematocrit differences in the association between cardiopulmonary bypass reoxygenation and acute kidney injury following Tetralogy of Fallot repair.
We investigated the association of perfusate oxygenation during aortic occlusion associated with acute kidney injury between 204 normal and 248 higher haematocrit children with Tetralogy of Fallot, aged 1 month-18 years, who were surgically repaired in 2012-2018. Normal and higher haematocrit children were defined as having a preoperative haematocrit within and above age- and sex-specific reference intervals, respectively. Acute kidney injury was determined as a binary variable according to the Kidney Disease Improving Global Outcomes criteria.
After adjusting for baseline and clinical covariates, a significant interaction between the haematocrit and continuous perfusate oxygenation on acute kidney injury was found (pinteraction = 0.049): a higher perfusate oxygenation was associated with a greater acute kidney injury risk among higher haematocrit children (adjusted odds ratio = 1.50, 95% confidence interval = [1.02, 2.22] per SD, p = 0.038) but not among normal haematocrit children (adjusted odds ratio = 0.91, 95% confidence interval = [0.51, 1.63] per SD, p = 0.73). After a similar adjustment, there was a marginal interaction between tertiles of perfusate oxygenation and haematocrit on acute kidney injury (pinteraction = 0.09): the middle and top tertiles of perfusate oxygenation were associated with a trend towards increased acute kidney injury risks among higher haematocrit children (adjusted odds ratio = 1.69, 95% confidence interval = [0.61, 4.66]; adjusted odds ratio = 2.25, 95% confidence interval = [0.84, 5.99], respectively) but not among normal haematocrit children (adjusted odds ratio = 1.16, 95% confidence interval = [0.46, 2.94]; adjusted odds ratio = 0.45, 95% confidence interval = [0.15, 1.36], respectively) compared with the bottom tertile.
Preoperative haematocrit differences significantly modify the association of perfusate oxygenation with acute kidney injury, highlighting differential control of reoxygenation for different haematocrit children with Tetralogy of Fallot in the management of cardiopulmonary bypass.
基金：
Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [3332018189]; National Clinical Key Specialty Construction Projects of China
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区外周血管病
最新[2023]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区外周血管病
JCR分区：
出版当年[2017]版：
Q4PERIPHERAL VASCULAR DISEASEQ4CARDIAC & CARDIOVASCULAR SYSTEMS
第一作者机构：[1]Graduate School, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China
通讯作者：
通讯机构：[2]Department of Cardiovascular Surgery and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China[*1]Department of Cardiovascular Surgery and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
推荐引用方式(GB/T 7714)：
Liu Hong,Zheng Si-Qiang,Qian Si-Chong,et al.Haematocrit differences modify the association of cardiopulmonary bypass reoxygenation with acute kidney injury after paediatric Tetralogy of Fallot repair.[J].PERFUSION-UK.2019,267659119871777.doi:10.1177/0267659119871777.
APA：
Liu Hong,Zheng Si-Qiang,Qian Si-Chong,He Huang-He&Xue Jin-Rong.(2019).Haematocrit differences modify the association of cardiopulmonary bypass reoxygenation with acute kidney injury after paediatric Tetralogy of Fallot repair..PERFUSION-UK,,
MLA：
Liu Hong,et al."Haematocrit differences modify the association of cardiopulmonary bypass reoxygenation with acute kidney injury after paediatric Tetralogy of Fallot repair.".PERFUSION-UK .(2019):267659119871777
