Botulinum toxin A (BTX-A) protects against primary ischaemia of skin flaps, but its effect on secondary ischaemia is unknown. We induced secondary arterial or venous ischaemia in skin flaps of 32 Wistar rats, and tested the effectiveness of BTX injected subcutaneously 12hours before the flap was raised. The animals were divided into two groups of 16 (arterial or venous). Eight animals in each group were then treated with saline 1ml (control), and eight with BTX-A 5 IU (treatment). Ischaemia and necrosis were assessed after five days. There was no significant difference in necrosis between the two treatments in either group, but the amount of ischaemia did differ significantly (p=0.031 in the artetial ishcemia and p=0.015 in the venous ischemia group). BTX helped to salvage poor reperfusion in secondary ischaemia of skin flaps. (c) 2017 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区牙科与口腔外科4 区外科
最新[2023]版：
大类|4 区医学
小类|4 区牙科与口腔外科4 区外科
JCR分区：
出版当年[2016]版：
Q3DENTISTRY, ORAL SURGERY & MEDICINEQ3SURGERY
最新[2023]版：
Q2SURGERYQ2DENTISTRY, ORAL SURGERY & MEDICINEQ3DENTISTRY, ORAL SURGERY & MEDICINE
第一作者机构：[1]Plastic and Reconstructive Surgery, Beijing Anzhen Hospital, Capital Medical University, China
通讯作者：
通讯机构：[1]Plastic and Reconstructive Surgery, Beijing Anzhen Hospital, Capital Medical University, China
推荐引用方式(GB/T 7714)：
Huang L..Beneficial effect of botulinum toxin A on secondary ischaemic injury of skin flaps in rats[J].BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY.2018,56(2):144-147.doi:10.1016/j.bjoms.2017.04.008.
APA：
Huang, L..(2018).Beneficial effect of botulinum toxin A on secondary ischaemic injury of skin flaps in rats.BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY,56,(2)
MLA：
Huang, L.."Beneficial effect of botulinum toxin A on secondary ischaemic injury of skin flaps in rats".BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY 56..2(2018):144-147
