机构：[1]Department of Infectious Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China临床科室感染科首都医科大学附属安贞医院[2]Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China内科系统(本部)呼吸科（本部）北京朝阳医院[3]Department of Pulmonary and Critical Care Medicine, Center for Respiratory Diseases, China-Japan Friendship Hospital,National Clinical Research Center for Respiratory Diseases, Beijing, China
ObjectiveTo investigate the incidence and risk factors of lung cancer in patients with idiopathic pulmonary fibrosis (IPF), and to learn the clinical, imaging and pathological features and of lung cancer in IPF. MethodsThe study population included consecutive 268 IPF patients. Of them, 46 patients had pathologically or cytologically proven lung cancer. The demographic, clinical, HRCT and pathological features in patients with IPF and lung cancer were analysed and compared with the patients with IPF alone. ResultsOf 268 IPF patients, 46 patients were diagnosed as IPF with lung cancer, accounted for 17.16%. 45.65% were adenocarcinoma. Lung cancer located mostly in the peripheral area and lower lobes of lungs consistent with IPF affected area. Old age and heavy smoking were risk factors of lung cancer developing in IPF. Chest pain and haemoptysis were more frequent in IPF patients with lung cancer than without lung cancer (P=.000). Nodular or mass shadows were found only in IPF patients with lung cancer (P=.000). The levels of CEA and CA125 in IPF patients were much higher in IPF patients with lung cancer (P.001). The median survival time was 36.222.7 months in IPF patients, longer than 6.9 +/- 3.3 months in IPF patients with lung cancer (P<.001). ConclusionsLung cancer frequently develops in patients with IPF, which is mainly adenocarcinoma, located in IPF affected area. Chest pain and haemoptysis are potential indicative of lung cancer developing in patients with IPF as atypical nodes or masses located in the peripheral areas and lower lobes on chest HRCT.
基金：
Key Program of National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81430001]; National Key Technologies R & D Program Precision Medicine Research [2016YFC0901101]
第一作者机构：[1]Department of Infectious Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China[2]Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China[3]Department of Pulmonary and Critical Care Medicine, Center for Respiratory Diseases, China-Japan Friendship Hospital,National Clinical Research Center for Respiratory Diseases, Beijing, China[*1]Department of Pulmonary and Critical Care Medicine, Center for Respiratory Diseases, China-Japan Friendship Hospital,National Clinical Research Center for Respiratory Diseases, No. 2 Yinghua Dongjie, Beijing 100029, China.
推荐引用方式(GB/T 7714)：
Liu Yan,Zhu Min,Geng Jing,et al.Incidence and radiologic-pathological features of lung cancer in idiopathic pulmonary fibrosis[J].CLINICAL RESPIRATORY JOURNAL.2018,12(4):1700-1705.doi:10.1111/crj.12732.
APA：
Liu, Yan,Zhu, Min,Geng, Jing,Ban, Chengjun,Zhang, Shu...&Dai, Huaping.(2018).Incidence and radiologic-pathological features of lung cancer in idiopathic pulmonary fibrosis.CLINICAL RESPIRATORY JOURNAL,12,(4)
MLA：
Liu, Yan,et al."Incidence and radiologic-pathological features of lung cancer in idiopathic pulmonary fibrosis".CLINICAL RESPIRATORY JOURNAL 12..4(2018):1700-1705
