Background Obstructive sleep apnea (OSA) is a common disease in patients with acute coronary syndrome (ACS) and associated with an increased risk of fatal and nonfatal cardiovascular events. However, most patients in previous study were treated with bare metal stents and the sample sizes were relatively low. The goal of this study was to evaluate the influence of OSA on the severity and prognosis of patients admitted for ACS. Methods In this prospective cohort study, we enrolled patients with ACS who were hospitalized for coronary angiogram/percutaneous coronary intervention and undergone polysomnography. We divided the patients into two groups: moderate to severe OSA group [apnea-hypopnea index (AHI) < 15 events/h] and control group (AHI <= 15 events/h). They were followed up for up 32 months. Then, we compared the ACS severity and long-term major adverse cardiovascular events (MACE) in patients with different severity of OSA. Results Five hundred and twenty nine patients were included in the final analysis, with 76% of them being men and an average age of 59 +/- 10 years. The overall mean AHI is 29 +/- 19 events/h, 70.5% of them (373/529) being with moderate to severe OSA and 29.5% (156/529) assign into control group. Compared with controls, patients with moderate or severe OSA exhibited a higher prevalence of hypertension as well as higher body mass index, SYNTAX score, Epworth score and length of hospitalization. With a median follow-up duration of 30 months, accumulative rate of MACE was also higher in patients with moderate or severe OSA than that in the control group (8.6% vs. 3.2%, P = 0.028). After adjusting for baseline confounders by cox regression model, moderate to severe OSA was an independent risk factor of long-term MACE (P = 0.047, HR = 1.618, 95% CI: 1.069-3.869). Conclusions The results of this study demonstrate that moderate or severe OSA is correlated with disease severity and associated with worse long-term prognosis in ACS patients. The results raising the possibility that early diagnose and interventions of OSA could improve long-term outcomes in ACS patients.
基金：
National Key Research and Development Program of China [2017 YFC0908800]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201303]; National Key Clinical speciality Construction Project; "Beijing Municipal Administration of Hospitals" Ascent Plan [DFL20150601]
第一作者机构：[1]Bejing Anzhen Hospital,Capital Medical University,Beijing Institute ofHeart Lung and Blood Vessel Disease,Beijing,China
通讯作者：
通讯机构：[1]Bejing Anzhen Hospital,Capital Medical University,Beijing Institute ofHeart Lung and Blood Vessel Disease,Beijing,China [*1]Department of Cardiology, Beijing Anzhen Hospital，Capital Medical University,Anzhenli avenue，Chao Yang district，Beijing 100029，China
推荐引用方式(GB/T 7714)：
Jia Shuo,Zhou Yu-Jie,Yu Yi,et al.Obstructive sleep apnea is associated with severity and long-term prognosis of acute coronary syndrome[J].JOURNAL OF GERIATRIC CARDIOLOGY.2018,15(2):146-152.doi:10.11909/j.issn.1671-5411.2018.02.005.
APA：
Jia, Shuo,Zhou, Yu-Jie,Yu, Yi,Wu, Si-Jing,Sun, Yan...&Zhou, Zhi-Ming.(2018).Obstructive sleep apnea is associated with severity and long-term prognosis of acute coronary syndrome.JOURNAL OF GERIATRIC CARDIOLOGY,15,(2)
MLA：
Jia, Shuo,et al."Obstructive sleep apnea is associated with severity and long-term prognosis of acute coronary syndrome".JOURNAL OF GERIATRIC CARDIOLOGY 15..2(2018):146-152
