Influence of high-flow modified ultrafiltration on brain oxygenation and perfusion during surgery for children with ventricular septal defects: a pilot study
机构：[1]Department of Extracorporeal Circulation, Centre for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China临床科室心脏外科危重症中心首都医科大学附属安贞医院[2]Department of Biomedical Engineering, Medical School, Tsinghua University, Beijing, China
Background: Modified ultrafiltration (MUF) can be performed in infants with ventricular septal defects (VSDs) after cardiopulmonary bypass (CPB) to reduce haemodilution and its potential adverse effects. High-flow MUF might reduce ultrafiltration duration and hasten the necessary correction of haemodilution during CPB. However, its influence on brain oxygenation remains controversial. Objective: This non-randomized, prospective, pilot study aimed to investigate the influence of high-flow MUF on brain oxygenation in infants with VSDs. Methods: High-flow MUF (20 mL/kg/min) was performed in twenty infants. Brain oxygen saturation (rSO(2)) and tissue haemoglobin index (tHI) were non-invasively and continuously measured intraoperatively using near-infrared spectroscopy (NIRS). Transcranial Doppler non-invasively detected the mean flow velocity of the middle cerebral artery (Vmean). Results: rSO(2) increased significantly during MUF, as did tHI, Vmean, mean arterial pressure and haematocrit (all p<0.05). No correlation was found between changes in rSO(2) and changes in other parameters (all p0.05). Conclusion: In infants with ventricular septal defects managed with CPB during VSDs repair, high-flow MUF did not reduce brain oxygenation.
基金：
Foundation of Beijing Anzhen Hospital, Capital Medical University [2016C01]; National Key Research and Development Program of China [2016YFC1301001]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区外周血管病
最新[2023]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区外周血管病
JCR分区：
出版当年[2016]版：
Q4PERIPHERAL VASCULAR DISEASEQ4CARDIAC & CARDIOVASCULAR SYSTEMS
第一作者机构：[1]Department of Extracorporeal Circulation, Centre for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Extracorporeal Circulation, Centre for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China[*1]Department of Extracorporeal Circulation, Centre for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, 2 Anzhen Road, Chaoyang District, Beijing 100029, China.
推荐引用方式(GB/T 7714)：
Jia Zaishen,Teng Yichao,Liu Yuan,et al.Influence of high-flow modified ultrafiltration on brain oxygenation and perfusion during surgery for children with ventricular septal defects: a pilot study[J].PERFUSION-UK.2018,33(3):203-208.doi:10.1177/0267659117736120.
APA：
Jia, Zaishen,Teng, Yichao,Liu, Yuan,Wang, Hong,Li, Yue&Hou, Xiaotong.(2018).Influence of high-flow modified ultrafiltration on brain oxygenation and perfusion during surgery for children with ventricular septal defects: a pilot study.PERFUSION-UK,33,(3)
MLA：
Jia, Zaishen,et al."Influence of high-flow modified ultrafiltration on brain oxygenation and perfusion during surgery for children with ventricular septal defects: a pilot study".PERFUSION-UK 33..3(2018):203-208
