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Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

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收录情况： ◇ SCIE

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机构： [1]Beijing Hosp, Natl Clin Res Ctr Resp Dis, Beijing 100730, Peoples R China; [2]Capital Med Univ, Beijing An Zhen Hosp, Dept Surg Intens Care Med, 2 Anzhen Rd, Beijing 100029, Peoples R China; [3]China Japan Friendship Hosp, Dept Pulm & Crit Care Med, 2 Yinghua Dongjie, Beijing 100029, Peoples R China; [4]Beijing Hosp, Dept Pulm & Crit Care Med, Beijing 100730, Peoples R China; [5]Beijing Hosp, Key Lab Geriatr, Beijing, Peoples R China; [6]Minist Hlth, Beijing Inst Geriatr, Beijing, Peoples R China

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关键词： ARDS Cytokine storm Hemoadsorption Porcine model Proteomics

摘要：

Background: Blood purification is an emerging approach to dampening the cytokine storm. This study aims to assess the efficacy of HA330 resin-directed hemoadsorption (HA) on endotoxin-induced porcine acute respiratory distress syndrome (ARDS) model. Methods: Twenty-four Chinese domestic pigs were allocated into saline group receiving intravenous infusion of saline (N = 6) and endotoxin group receiving intravenous infusion of LPS (N = 18). When ALI model was initially diagnosed, six pigs in the LPS and saline group were killed for BALF and histopathological analysis. The remaining 12 pigs in LPS group received 3-h HA (N = 6) or HA-sham (N = 6) treatment, respectively. Following another 5-h observation, animals were killed. Variables on hemodynamics, blood gases and lung mechanics were recorded at a series of time points. Differentially expressed cytokines and proteins were determined by ELISA and proteomics. Results: HA treatment significantly improved injured oxygenation induced by LPS. HA also partially improved the barrier permeability and reduced lung edema and inflammation/injury induced by LPS infusion. Proteomic analysis showed the differentially expressed proteins between HA-and HA-sham-treated groups mostly belonged to the categories of acute inflammation/immune response, and proteolysis. Conclusions: Hemoadsorption improved ARDS possibly by blunting the cytokine storm and by restoring homeostasis of the disordered proteome milieu in the exudative phase.

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中科院(CAS)分区：

出版当年[2016]版中科院分区表Review为是的期刊

：

大类 | 2 区医学

小类 | 3 区危重病医学

最新[2023]版：

大类 | 1 区

医学

小类 | 2 区危重病医学

JCR分区：

出版当年[2015]版：

Q1 CRITICAL CARE MEDICINE

最新[2023]版：

Q1 CRITICAL CARE MEDICINE

影响因子： 5.7 最新[2023版] 6 最新五年平均 4.529 出版当年[2015版] 4.294 出版当年五年平均 3.311 出版前一年[2014版] 3.656 出版后一年[2016版]

第一作者：

第一作者机构： [1]Beijing Hosp, Natl Clin Res Ctr Resp Dis, Beijing 100730, Peoples R China; [2]Capital Med Univ, Beijing An Zhen Hosp, Dept Surg Intens Care Med, 2 Anzhen Rd, Beijing 100029, Peoples R China;

通讯作者：

通讯机构： [1]Beijing Hosp, Natl Clin Res Ctr Resp Dis, Beijing 100730, Peoples R China; [3]China Japan Friendship Hosp, Dept Pulm & Crit Care Med, 2 Yinghua Dongjie, Beijing 100029, Peoples R China;

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