A small implantable centrifugal left ventricular assist device, the CH-VAD (CH Biomedical Inc, JiangSu, China), featuring a magnetically levitated impeller is under development. The goal of this study is to validate hydrodynamic performance and hemocompatibility of the pump through in vitro studies. The hydraulic performance was quantified experimentally by using in vitro circulation loop system, and it turned out that the pump could deliver 5 L/min under a pressure of 100 mmHg at a rotational speed of approximate 3400 rpm. A series of in vitro tests were established according to ASTM F1841, the standard practice for the assessment of hemolysis in continuous-flow blood pumps. The results showed that the average normalized index of hemolysis (NIH) value of the VAD was 0.0007 +/- 0.0003 mg/dL. The magnetic levitation left ventricular assist device (LVAD) has good hemolytic performance and stable mechanical property. These acceptable performance results supported proceeding initial acute animal testing conditions.
基金:
National High Technology Research and Development Program of ChinaNational High Technology Research and Development Program of China [2012AA041605]; National Science Foundation of ChinaNational Natural Science Foundation of China [81670371]
通讯机构:[1]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China;[2]Beijing Univ Technol, Coll Life Sci & Bioengn, PingLeYuan Str 100, Beijing 100029, Peoples R China;
推荐引用方式(GB/T 7714):
Wu Guanghui,Xu Chuangye,Liu Xiujian,et al.HYDRAULICS AND IN VITRO HEMOLYSIS TEST OF A MAGLEV IMPLANTABLE VENTRICULAR ASSIST DEVICE[J].JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY.2017,17(7):-.doi:10.1142/S0219519417400231.
APA:
Wu, Guanghui,Xu, Chuangye,Liu, Xiujian,Lin, Changyan,Yang, Lin...&Yang, Peng.(2017).HYDRAULICS AND IN VITRO HEMOLYSIS TEST OF A MAGLEV IMPLANTABLE VENTRICULAR ASSIST DEVICE.JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY,17,(7)
MLA:
Wu, Guanghui,et al."HYDRAULICS AND IN VITRO HEMOLYSIS TEST OF A MAGLEV IMPLANTABLE VENTRICULAR ASSIST DEVICE".JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY 17..7(2017):-