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HYDRAULICS AND IN VITRO HEMOLYSIS TEST OF A MAGLEV IMPLANTABLE VENTRICULAR ASSIST DEVICE

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收录情况: ◇ SCIE ◇ CPCI(ISTP) ◇ EI

机构: [1]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China; [2]Beijing Univ Technol, Coll Life Sci & Bioengn, PingLeYuan Str 100, Beijing 100029, Peoples R China; [3]Capital Med Univ, Beijing Anzhen Hosp, AnZhen Str 2, Beijing 100029, Peoples R China; [4]CH Biomed Inc, Suzhou Ind Pk,East Bldg 2-6,Room 202, Nanjing 215125, Jiangsu, Peoples R China
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关键词: Left ventricular assist device (LVAD) magnetic levitation in vitro hemolysis test normalized index of hemolysis (NIH)

摘要:
A small implantable centrifugal left ventricular assist device, the CH-VAD (CH Biomedical Inc, JiangSu, China), featuring a magnetically levitated impeller is under development. The goal of this study is to validate hydrodynamic performance and hemocompatibility of the pump through in vitro studies. The hydraulic performance was quantified experimentally by using in vitro circulation loop system, and it turned out that the pump could deliver 5 L/min under a pressure of 100 mmHg at a rotational speed of approximate 3400 rpm. A series of in vitro tests were established according to ASTM F1841, the standard practice for the assessment of hemolysis in continuous-flow blood pumps. The results showed that the average normalized index of hemolysis (NIH) value of the VAD was 0.0007 +/- 0.0003 mg/dL. The magnetic levitation left ventricular assist device (LVAD) has good hemolytic performance and stable mechanical property. These acceptable performance results supported proceeding initial acute animal testing conditions.

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出版当年[2016]版:
大类 | 4 区 工程技术
小类 | 4 区 生物物理 4 区 工程:生物医学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 生物物理 4 区 工程:生物医学
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出版当年[2015]版:
Q4 ENGINEERING, BIOMEDICAL Q4 BIOPHYSICS
最新[2023]版:
Q4 ENGINEERING, BIOMEDICAL Q4 BIOPHYSICS

影响因子: 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

第一作者:
第一作者机构: [1]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China;
通讯作者:
通讯机构: [1]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China; [2]Beijing Univ Technol, Coll Life Sci & Bioengn, PingLeYuan Str 100, Beijing 100029, Peoples R China;
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