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Changes in Enteric Neurons of Small Intestine in a Rat Model of Irritable Bowel Syndrome with Diarrhea

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机构: [1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Gastroenterol, 1 Shuaifuyuan, Beijing 100730, Peoples R China; [2]Peking Union Med Coll, 1 Shuaifuyuan, Beijing 100021, Peoples R China; [3]Capital Med Univ, Beijing Anzhen Hosp, Dept Gastroenterol, Beijing, Peoples R China; [4]Ohio State Univ, Wexner Med Ctr, Dept Physiol & Cell Biol, Columbus, OH 43210 USA
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关键词: Diarrhea Enteric nervous system Gastrointestinal motility Irritable bowel syndrome

摘要:
Background/Aims Physical and/or emotional stresses are important factors in the exacerbation of symptoms in irritable bowel syndrome (IBS). Several lines of evidence support that a major impact of stress on the gastrointestinal tract occurs via the enteric nervous system. We aimed to evaluate histological changes in the submucosal plexus (SMP) and myenteric plexus (MP) of the distal ileum in concert with the intestinal motor function in a rat model of IBS with diarrhea. Methods The rat model was induced by heterotypic chronic and acute stress (CAS). The intestinal transit was measured by administering powdered carbon by gastric gavage. Double immunohistochemical fluorescence staining with whole-mount preparations of SMP and MP of enteric nervous system was used to assess changes in expression of choline acetyltransferase, vasoactive intestinal peptide, or nitric oxide synthase in relation to the pan neuronal marker, anti-Hu. Results The intestinal transit ratio increased significantly from control values of 50.8% to 60.6% in the CAS group. The numbers of enteric ganglia and neurons in the SMP were increased in the CAS group. The proportions of choline acetyltransferase- and vasoactive intestinal peptide-immunoreactive neurons in the SMP were increased (82.1 +/- 4.3% vs. 76.0 +/- 5.0%, P = 0.021; 40.5 +/- 5.9% vs 28.9 +/- 3.7%, P = 0.001), while nitric oxide synthase-immunoreactive neurons in the MP were decreased compared with controls (23.3 +/- 4.5% vs 32.4 +/- 4.5%, P = 0.002). Conclusions These morphological changes in enteric neurons to CAS might contribute to the dysfunction in motility and secretion in IBS with diarrhea.

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出版当年[2015]版:
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 胃肠肝病学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 胃肠肝病学
JCR分区:
出版当年[2014]版:
Q3 GASTROENTEROLOGY & HEPATOLOGY Q3 CLINICAL NEUROLOGY
最新[2023]版:
Q2 CLINICAL NEUROLOGY Q2 GASTROENTEROLOGY & HEPATOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

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第一作者机构: [1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Gastroenterol, 1 Shuaifuyuan, Beijing 100730, Peoples R China; [2]Peking Union Med Coll, 1 Shuaifuyuan, Beijing 100021, Peoples R China; [3]Capital Med Univ, Beijing Anzhen Hosp, Dept Gastroenterol, Beijing, Peoples R China;
通讯作者:
通讯机构: [1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Gastroenterol, 1 Shuaifuyuan, Beijing 100730, Peoples R China; [2]Peking Union Med Coll, 1 Shuaifuyuan, Beijing 100021, Peoples R China;
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