The treatment of plaques near and involving coronary bifurcations(CB) is especially challenging, considering more plaques localized these regions and higher post-interventional in-stent restenosis (ISR) risk, mainly due to hemodynamic injury provoked on the arterial wall. Therefore optimization of stenting should begin with an understanding of how disease localized to these regions and why ISR formed associated with flow patterns. We chose four patients with bifurcation lesions, two patients with ISR and two without ISR according to the follow-up computed tomography angiography (CTA). Based on patient-specific pre-interventional and virtual stented geometries from CTA images, numerical simulation indicated that the wall shear stress (WSS) in stented segments, where the ISR occurred in one year, was lower than those without ISR, however. For bifurcation lesion, the stenting segments WSS is supposed a marker to forecast the ISR risk after stent treatment. © (2014) Trans Tech Publications, Switzerland.