Objective: To observe the application of McGiIl pain questionnaire (MPQ) in discrimination and diagnosis of trigeminal neuralgia and assessment of therapeutic effect of radiofrequency diermocoagulation (RFT) on trigeminal neuralgia. Method: There were 159 trigeminal neuralgia patients enrolled in this study, of which 136 classic trigeminal neuralgia (CTN) patients and 23 mixed trigeminal neuralgia (MTN) patients. MPQ was used to identify the pain, and observe the pain relieving after RFT in 124 patients of which. Result: The mean present pain index (PPI) of CTN group was 4.20±0.34, and diat of MTN group was 3.50±0.57 (P<0.001); In pain rating index(PRI)-sensory subscale, the patients with CTN reported higher pain intensity in terms of sensory experience than patients with MTN (P<.001); The PRI-affective and PRI-evaluative dimensions of pain were significandy different between two groups, the scores were higher in CTN group (P<0.001). Overall, 103 (93.6%) patients in CTN group responded to RFT with higher immediate improvements in self-report. In MTN group, only 10(58.8%) patients in MTN group responded to RFT with significant improvements in self-report. Conclusion: The application of MPQ could discriminate different type of trigeminal neuralgia well. In view of the different effectiveness in two type of trigeminal neuralgia after RFT, MPQ played an important role in diagnosis, discrimination and therapeutic effect assessment of trigeminal neuralgia.