机构：[a]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China放射科首都医科大学宣武医院[b]Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China神经外科首都医科大学宣武医院[c]Department of Medicine, University of Melbourne, Parkville 3010, Australia[d]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, PR China[e]Beijing Key laboratory of MRI and Brain Informatics, Beijing, PR China
Objective: To investigate microstructural tissue changes of trigeminal nerve (TGN) in patients with unilateral trigeminal neuralgia (TN) by multiple diffusion metrics, and correlate the diffusion indexes with the clinical variables. Methods: 16 patients with TN and 6 healthy controls (HC) were recruited into our study. All participants were imaged with a 3.0 T system with three-dimension time-of-flight (TOF) magnetic resonance angiography and fluid attenuated inversion recovery (FLAIR) DTI-sequence. We placed regions of interest over the root entry zone of the TGN and measured fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD). The mean values of FA, MD, AD and RD were compared between the affected and unaffected sides in the same patient, and to HC values. The correlation between the side-to-side diffusion metric difference and clinical variables (disease duration and visual analogy scale, VAS) was further explored. Results: Compared with the unaffected side and HC, the affected side showed significantly decreased FA and increased RD; however, no significant changes of AD were found. A trend toward significantly increased MD was identified on the affected side comparing with the unaffected side. We also found the significant correlation between the FA reduction and VAS of pain (r = -0.55, p = 0.03). Conclusion: DTI can quantitatively assess the microstructural abnormalities of the affected TGN in patients with TN. Our results suggest demyelination without significant axonal injury is the essential pathological basis of the affected TGN by multiple diffusion metrics. The correlation between FA reduction and VAS suggests FA as a potential objective MRI biomarker to correlate with clinical severity. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
基金：
the State Key Program of National Natural Science of China (No. 30930029)
the National Science Foundation of China (Nos. 81000633 and 81101038)
第一作者机构：[a]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China[e]Beijing Key laboratory of MRI and Brain Informatics, Beijing, PR China
共同第一作者：
通讯作者：
通讯机构：[a]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China[b]Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China
推荐引用方式(GB/T 7714)：
Yaou Liu,Jiping Li,Helmut Butzkueven,et al.Microstructural abnormalities in the trigeminal nerves of patients with trigeminal neuralgia revealed by multiple diffusion metrics[J].EUROPEAN JOURNAL OF RADIOLOGY.2013,82(5):783-786.doi:10.1016/j.ejrad.2012.11.027.
APA：
Yaou Liu,Jiping Li,Helmut Butzkueven,Yunyun Duan,Mo Zhang...&Kuncheng Li.(2013).Microstructural abnormalities in the trigeminal nerves of patients with trigeminal neuralgia revealed by multiple diffusion metrics.EUROPEAN JOURNAL OF RADIOLOGY,82,(5)
MLA：
Yaou Liu,et al."Microstructural abnormalities in the trigeminal nerves of patients with trigeminal neuralgia revealed by multiple diffusion metrics".EUROPEAN JOURNAL OF RADIOLOGY 82..5(2013):783-786
