Telomeres and telomerase play important roles in the occurrence and development of hypertension. This review was performed to clarify the factors that influence telomere length and telomerase activity in older patients and elucidate the association of these factors with hypertension. A PubMed search and critical review of studies assessing the risk factors underlying the association of hypertension with telomere length and telomerase activity was performed. Telomere length and telomerase activity were found to be associated with hypertension. The factors that influence telomere length and telomerase activity in older patients with hypertension include genetics, demographics, social and environmental factors, chronic disease, psychological factors, and antihypertensive drug treatment. A better understanding of the molecular mechanisms underlying the association of hypertension with telomere length and telomerase activity may help to reduce the incidence of hypertension.
基金：
国家自然科学基金
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2017]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Liu Pan,Zhang Yaxin,Ma Lina.Telomere length and associated factors in older adults with hypertension[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2019,47(11):5465-5474.doi:10.1177/0300060519882570.
APA：
Liu, Pan,Zhang, Yaxin&Ma, Lina.(2019).Telomere length and associated factors in older adults with hypertension.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,47,(11)
MLA：
Liu, Pan,et al."Telomere length and associated factors in older adults with hypertension".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 47..11(2019):5465-5474
