Objectives: This review aims to clarify the relationship between telomeres and essential hypertension. Design and methods: A PubMed search and a critical review were performed relating to studies about the clinical and biological relevance of telomeres in essential hypertension. Results: Telomeres and telomerase activity play an important role in the occurrence and development of hypertension in both animal and human studies. Conclusions: A more complete understanding of the molecular mechanisms underlying the development of hypertension could reduce the incidence of hypertension-related diseases. (C) 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
基金:
Ministry of Education in China Project of Humanities and Social Sciences (12YJCZH146),
Beijing Excellent Talent Fund (20140000204400001)
Beijing Municipal Health Bureau Research Fund (Jing 13-02).