机构：[1]Center on Translational Neuroscience, College of Life and Environment Sciences, Minzu University of China, Beijing 100081, China.[2]Children's Minnesota Research Institute, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN 55404, USA.[3]Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.[4]Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.职能科室临床流行病与循证医学中心首都医科大学附属北京儿童医院[5]Department of Biostatistics, School of Public Health, Shandong University, Jinan, Shandong 250012, China.
This study aimed to dissect the direct effect of smoking and its indirect effect through body mass index (BMI) on leukocyte telomere length (LTL) and to distinguish the mediation and suppression effects of BMI. The study cohort included 1,037 adults (729 Whites and 308 African Americans; 42.1% males; mean age: 40.3 years) with LTL measurements by Southern blotting. General third variable models were used to distinguish the mediation and suppression effects of BMI on the smoking-LTL association. After adjusting for age, race, sex and alcohol drinking, the total effect of smoking on LTL was significant (standardized regression coefficient, β= -0.061, p=0.034) without BMI included in the model. With additional adjustment for BMI, the indirect effect of smoking on LTL through BMI was estimated at β= 0.011 (p=0.023), and the direct effect of smoking on LTL was strengthened to β= -0.072 (p=0.012). The results were similar when pack-years of smoking was used. The effect parameters did not differ significantly between race and sex groups. These results suggest that BMI has a suppression effect, not a mediation effect, on the smoking-LTL association, which potentially contributes to previous inconsistencies in the effect of smoking on LTL.
基金：
This study was supported by grants R03AG060619 from National Institute on Aging, R01HL121230 from the National Heart, Lung and Blood Institute, and P20GM109036 from the National Institute of General Medical Sciences of the National Institutes of Health. Miaoying Yun is partly supported by the MUC 111 Project from Minzu University of China.
第一作者机构：[1]Center on Translational Neuroscience, College of Life and Environment Sciences, Minzu University of China, Beijing 100081, China.
推荐引用方式(GB/T 7714)：
Yun Miaoying,Li Shengxu,Yan Yinkun,et al.Suppression effect of body weight on the association between cigarette smoking and telomere length: the Bogalusa Heart Study.[J].AGING-US.2019,11(21):9893-9900.doi:10.18632/aging.102439.
APA：
Yun Miaoying,Li Shengxu,Yan Yinkun,Zhang Tao,Bazzano Lydia...&Chen Wei.(2019).Suppression effect of body weight on the association between cigarette smoking and telomere length: the Bogalusa Heart Study..AGING-US,11,(21)
MLA：
Yun Miaoying,et al."Suppression effect of body weight on the association between cigarette smoking and telomere length: the Bogalusa Heart Study.".AGING-US 11..21(2019):9893-9900
