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The improvement of infantile atopic dermatitis during the maintenance period: A multicenter, randomized, parallel controlled clinical study of emollients in Prinsepia utilis Royle.

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资源类型：

收录情况： ◇ SCIE

作者：
Wang Shan[1] * ; Wang Liuhui[2] ; Li Ping[3] ; Shu Hong[4] ; Shen Chunping[1] ; Wu Yao[2] ; Luo Zhen[3] ; Miao Limin[4] ; Wang Hongbing[5] ; Jiao Lei[1] ; Tian Jing[1] ; Peng Xiaoxia[6] ; Zhao Mutong[1] ; Liu Ying[1] ; Nie Xiaolu[6] ; He Li[5] ; Ma Lin[1] ;
机构： [1]Department of Dermatology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China [2]Department of Dermatology, Children's Hospital of Fudan University, Shanghai 201102, China [3]Department of Dermatology, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China [4]Department of Dermatology, Kunming Children's Hospital, Kunming 650000, Yunnan, China [5]Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China [6]Center for Clinical Epidemiology and Evidence⁃ based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
出处：
DOI： 10.1111/dth.13153
ISSN：

关键词： atopic dermatitis eczema emollients topical therapy

摘要：
In order to investigate the effect of daily emollient treatment on infantile atopic dermatitis (AD) during the maintenance period, a total of 309 children younger than 2 years with moderate AD (155 and 154 in the treatment and control groups, respectively) were enrolled in this multicenter, randomized, parallel controlled clinical trial. Subjects were topically treated with desonide cream and emollients in Prinsepia utilis Royle for 2-4 weeks before entering the maintenance period and then differentially treated with either emollients for treatment or none for control. The cumulative maintenance rate, time to flare and improvement of eczema area and severity index (EASI) and infant's dermatitis quality of life index (IDQOL) were evaluated. Results showed that the cumulative maintenance rate of the treatment group (60.5%, 95% CI 50.0-69.4%) was significantly higher than that of the control group (23.5%, 95% CI 15.2-33.0%) (p < .001). The median time to flare in the treatment group was 90 days (interquartile range, IQR 28-90), which was significantly longer than that in the control group (28 days [IQR 18-67]) (p < .001). At Week 4 in the maintenance period, the EASI and IDQOL scores of the treatment group were lower than those of the control group. In conclusion, the application of emollients during the maintenance period of infantile AD can significantly reduce the risk of AD flares, prolong the time to flare and improve the clinical symptoms. © 2019 Wiley Periodicals, Inc.

基金：
We thank all the investigators involved this study as well as the children and their caregivers who participated in this study. Financial support: the National Natural Science Foundation of China (81673042); the Pediatric Medical Coordinated Development Center of Beijing Municipal Administration (XTZD20180502); and the Beijing Talents Fund (2017000021469G248).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 4 区 医学
小类 | 4 区 皮肤病学
最新[2023]版：
大类 | 4 区 医学
小类 | 3 区 皮肤病学
JCR分区：
出版当年[2017]版：
Q3 DERMATOLOGY
最新[2023]版：
Q1 DERMATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Department of Dermatology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
通讯作者：
通讯机构： [1]Department of Dermatology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China [5]Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China
推荐引用方式(GB/T 7714)：
Wang Shan,Wang Liuhui,Li Ping,et al.The improvement of infantile atopic dermatitis during the maintenance period: A multicenter, randomized, parallel controlled clinical study of emollients in Prinsepia utilis Royle.[J].DERMATOLOGIC THERAPY.2019,e13153.doi:10.1111/dth.13153.
APA：
Wang Shan,Wang Liuhui,Li Ping,Shu Hong,Shen Chunping...&Ma Lin.(2019).The improvement of infantile atopic dermatitis during the maintenance period: A multicenter, randomized, parallel controlled clinical study of emollients in Prinsepia utilis Royle..DERMATOLOGIC THERAPY,,
MLA：
Wang Shan,et al."The improvement of infantile atopic dermatitis during the maintenance period: A multicenter, randomized, parallel controlled clinical study of emollients in Prinsepia utilis Royle.".DERMATOLOGIC THERAPY .(2019):e13153

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