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Characterization of Intestinal Microbiota and Probiotics Treatment in Children With Autism Spectrum Disorders in China.

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Pediatrics, Peking University First Hospital, Beijing, China, [2]Department of Pediatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, [3]Department of Pediatrics, Peking University People’s Hospital, Beijing, China, [4]National Center for Children‘s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China, [5]Children’s Encephalopathy Diagnosis and Rehabilitation Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China, [6]Center of Children Psychology and Behavior, Henan Maternal and Child Health Hospital, Zhengzhou, China, [7]The Children’s Hospital Zhejiang University School of Medicine, Hangzhou, China, [8]Department of Pediatric Rehabilitation, Jiningshi Renchengqu Women’s and Children’s Health Care Hospital, Jining, China, [9]Department of Pediatric Rehabilitation, Linyishi Women’s and Children’s Hospital, Linyi, China, [10]Beijing Gutgene Technology Co. Ltd, Beijing, China, [11]Xinxiang Central Hospital, Xinxiang, China

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关键词： autism spectrum disorder intestinal microbiota probiotics treatment children China

摘要：

Background: Most previous studies have found that human intestinal microbiota affect the symptoms of autism spectrum disorder (ASD), especially gastrointestinal (GI) symptoms, but regarding this, there is limited data of non-western ethnicity. Probiotics can reconstitute the host intestinal microbiota and strengthen gastrointestinal function, however, clinical data proving the effect of probiotics treatment on ASD is lacking. Methods: This study explored the significant differences between ASD and neurotypical (NT), and the improvement of applied behavior analysis (ABA) training in combination with probiotics, vs. ABA training only. Results: We found significant differences between the ASD group and the NT group in the evenness of the intestinal microbiota and the relative abundance of the bacterial phyla and genus. At the phylum level, relative abundance of Bacteroidetes in the ASD group was significantly lower than in the NT group. At the genus level, the relative abundance of Bacteroides, Bifidobacterium, Ruminococcus, Roseburia, and Blautia in the ASD group was significantly lower than that in the NT group. After a 4-week ABA training program in combination with probiotics treatment, the ATEC and GI scores decreased more than the control group with ABA training only. Conclusion: Our findings suggest that intestinal microbiota is different between the NT children and the ASD children with or without GI problems. In combination with ABA training, probiotics treatment can bring more benefit to ASD children. Clinical trials with a more rigorous design and larger sample size are indispensable for further validation. Copyright © 2019 Niu, Li, Zhang, Wen, Dang, Duan, Li, Ruan, Yang, Guan, Tian, Gao, Zhang, Yuan and Han.

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出版当年[2018]版：

大类 | 2 区医学

小类 | 3 区临床神经病学 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

JCR分区：

出版当年[2017]版：

Q2 NEUROSCIENCES Q2 CLINICAL NEUROLOGY

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 3.3 最新五年平均 3.508 出版当年[2017版] 4.297 出版当年五年平均 3.552 出版前一年[2016版] 2.635 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Pediatrics, Peking University First Hospital, Beijing, China, [2]Department of Pediatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,

通讯作者：

通讯机构： [1]Department of Pediatrics, Peking University First Hospital, Beijing, China,

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Characterization of Intestinal Microbiota and Probiotics Treatment in Children With Autism Spectrum Disorders in China.

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