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Molecular characteristics and antimicrobial susceptibility of Staphylococcus aureus among children with respiratory tract infections in southwest China

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收录情况： ◇ SCIE ◇ CSCD-C

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机构： [1]Pediatric Intensive Care Unit, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, NanLiShi Road 56, Xicheng District, Beijing 100045, China [2]Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China [3]Respiratory Department, Qilu Children’s Hospital, Shandong University, Jinan 250022, China [4]Department of Pediatrics, People’s Hospital of Zhongjiang County, No. 96 Da‑bei Street, Deyang 618100, China [5]Youyang Hospital, The First Affiliated Hospital of Chongqing Medical University, People’s Hospital of Chongqing Youyang County, Chongqing 409899, China

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关键词： Antimicrobial susceptibility Chinese children Molecular characteristics Staphylococcus aureus

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Background The molecular characteristics and antimicrobial susceptibility of Staphylococcus aureus (S. aureus) in general pediatric wards and county-level hospitals were rarely reported in China. Methods Staphylococcus aureus was isolated from children hospitalized with respiratory tract infection (RTI) in Zhongjiang and Youyang counties in 2015. All isolates were typed by multilocus sequence, staphylococcal protein A, accessory gene regulator (agr), and staphylococcal cassette chromosome mec [SCCmec, for methicillin-resistant S. aureus (MRSA) only]. Polymerase chain reaction was used to screen 21 super-antigen (SAg) genes and panton-valentine leukocidin (pvl). Antimicrobial susceptibility testing was performed by E test. Results A total of 2136 children were enrolled. Overall, 125 (5.9%) children carried S. aureus, among which MRSA accounted for 42.4%. ST59-SCCmec type IV-t437-agr group I (58.5%) was the most prevalent genotype in MRSA, and ST188-t189-agr group I (22.2%) was the top genotype in methicillin-sensitive S. aureus (MSSA). The pvl carriage rate in MRSA and MSSA was 15.1% and 9.7%, respectively (P = 0.4112). About 96.8% of S. aureus isolates were positive for at least one SAg gene. The most common SAg gene profile in the dominant ST59 clone was seb-sek-seq (42.8%). All S. aureus isolates were resistant to penicillin and erythromycin (minimum inhibitory concentration 90 was > 32 and 256 mg/L to penicillin and erythromycin, respectively), but usually susceptible to other tested non-beta-lactam antimicrobials. Conclusions Staphylococcus aureus and MRSA were detected with a high frequency in children with RTI in county-level hospitals of China. ST59-SCCmec type IV-t437-agr group I was the dominant MRSA clone. The S. aureus isolates exhibited high resistance to penicillin and erythromycin.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区儿科

最新[2023]版：

大类 | 2 区医学

小类 | 3 区儿科

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出版当年[2017]版：

Q3 PEDIATRICS

最新[2023]版：

Q1 PEDIATRICS

影响因子： 3.6 最新[2023版] 4.2 最新五年平均 1.228 出版当年[2017版] 1.304 出版当年五年平均 1.164 出版前一年[2016版] 1.169 出版后一年[2018版]

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第一作者机构： [1]Pediatric Intensive Care Unit, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, NanLiShi Road 56, Xicheng District, Beijing 100045, China

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通讯作者：

通讯机构： [1]Pediatric Intensive Care Unit, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, NanLiShi Road 56, Xicheng District, Beijing 100045, China

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Molecular characteristics and antimicrobial susceptibility of Staphylococcus aureus among children with respiratory tract infections in southwest China

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