机构：[1]Department of Medical Genetics, School of Basic MedicalSciences, Peking University Health Science Center,Beijing 100191, China[2]Department of Neurosurgery, Beijing Tiantan Hospital,Capital Medical University, Beijing 100050, China重点科室诊疗科室神经外科首都医科大学附属天坛医院[3]Beijing Neurosurgical Institute, Beijing 100050, China研究所北京市神经外科研究所首都医科大学附属天坛医院[4]The Second Affiliated Hospital of Zhejiang UniversitySchool of Medicine, Changxing Campus, Changxing 313100,China[5]Department of Hepatobiliary Surgery, National CancerCenter/Cancer Hospital, Chinese Academy of MedicalSciences and Peking Union Medical College, Beijing 100021,China[6]Department of Radiology, The First Hospital of HarbinMedical University, Harbin 150001, China[7]Department of Pathology, Beijing Ditan Hospital, CapitalMedical University, Beijing 100015, China[8]Sansure Biotech Inc., Changsha 410205, China[9]Department of Intervention Therapy, The Fourth MedicalCenter of PLA General Hospital, Beijing 100037, China[10]Department of Neurosurgery, Sanbo Brain Hospital, CapitalMedical University, Beijing 100093, China
Gliomas are the most commonly occurring tumors of the central nervous system. Glioblastoma multiforme (GBM) is the most malignant and aggressive brain cancer in adults. Further understanding of the mechanisms underlying the aggressive nature of GBM is urgently needed. Here we identified homeobox B8 (HOXB8), a member of the homeobox family, as a crucial contributor to the aggressiveness of GBM. Data mining of publicly accessible RNA sequence datasets and our patient cohorts confirmed a higher expression of HOXB8 in the tumor tissue of GBM patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rate. We next showed that HOXB8 promotes the proliferation and migration of glioblastoma cells and is crucial for the activation of the PI3K/AKT pathway and expression of epithelial-mesenchymal transition-related genes, possibly through direct binding to the promoter of SAMD9 (Sterile Alpha Motif Domain-Containing Protein 9) and activating its transcription. Collectively, we identified HOXB8 as a critical contributor to the aggressiveness of GBM, which provides insights into a potential therapeutic target for GBM and opens new avenues for improving its treatment outcome.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31571298]
第一作者机构：[1]Department of Medical Genetics, School of Basic MedicalSciences, Peking University Health Science Center,Beijing 100191, China[2]Department of Neurosurgery, Beijing Tiantan Hospital,Capital Medical University, Beijing 100050, China[3]Beijing Neurosurgical Institute, Beijing 100050, China
通讯作者：
通讯机构：[1]Department of Medical Genetics, School of Basic MedicalSciences, Peking University Health Science Center,Beijing 100191, China[9]Department of Intervention Therapy, The Fourth MedicalCenter of PLA General Hospital, Beijing 100037, China[10]Department of Neurosurgery, Sanbo Brain Hospital, CapitalMedical University, Beijing 100093, China
推荐引用方式(GB/T 7714)：
Wenping Ma,Hongze Jin,Wenjie Liu,et al.Homeobox B8 Targets Sterile Alpha Motif Domain-Containing Protein 9 and Drives Glioma Progression[J].Neuroscience bulletin.2019,-.doi:10.1007/s12264-019-00436-y.
APA：
Wenping Ma,Hongze Jin,Wenjie Liu,Xiaojuan Li,Xingang Zhou...&Hongshan Zhao.(2019).Homeobox B8 Targets Sterile Alpha Motif Domain-Containing Protein 9 and Drives Glioma Progression.Neuroscience bulletin,,
MLA：
Wenping Ma,et al."Homeobox B8 Targets Sterile Alpha Motif Domain-Containing Protein 9 and Drives Glioma Progression".Neuroscience bulletin .(2019):-
