详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

MicroRNA-21 Promotes Orthodontic Tooth Movement by Modulating the RANKL/OPG Balance in T Cells.

文献详情

资源类型：

收录情况： ◇ SCIE

作者：

机构： [1]Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University [2]Department of Stomatology, Beijing Tiantan Hospital, Capital Medical University [3]University of Pennsylvania, School of Dental Medicine,Peking University School of Stomatology the Third Dental Center 5 Department of Orthodontics, School of Stomatology, Capital Medical University [4]Department of Orthodontics, Peking University School of Stomatology the Third Dental Center [5]Department of Orthodontics, School of Stomatology, Capital Medical University

出处：

DOI：

ISSN：

关键词： bone remodeling microRNA 21 orthodontic osteoclast receptor activator of nuclear factor-κB ligand (RANKL) T cell

摘要：

The present study was designed to investigate the effects of microRNA-21 (miR-21) on orthodontic tooth movement. The orthodontic tooth movement model was established in C57BL/6 and miR-21-/- mice with or without implantation of activated T cells. Histological and histomorphometrical analyses were performed by hematoxylin-eosin staining. Tartrate-resistant acid phosphate staining was used to analyze the osteoclast numbers during tooth movement. Enzyme-linked immunosorbent assay, reverse transcription polymerase chain reaction and immunohistochemistry analysis were used to examine the expression of RANKL and OPG. In miR-21-/- mice, the distance of tooth movement was retarded, the osteoclast number was decreased, and serum RANKL expression was strongly reduced. MiR-21 promoted the secretion of RANKL from activated T cells. Furthermore, activated T cells could partially rescue the decreased orthodontic tooth movement distance in miR-21-/- mice. MiR-21 was shown to promote orthodontic tooth movement by modulating the RANKL/OPG balance in T cells. The impact of miR-21 on tooth movement was better elucidated, furthering our understanding of its role and clinical applications in orthodontics. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2018]版：

大类 | 4 区医学

小类 | 3 区牙科与口腔外科

最新[2023]版：

大类 | 3 区医学

小类 | 4 区牙科与口腔外科

JCR分区：

出版当年[2017]版：

Q1 DENTISTRY, ORAL SURGERY & MEDICINE

最新[2023]版：

Q1 DENTISTRY, ORAL SURGERY & MEDICINE

影响因子： 2.9 最新[2023版] 3.4 最新五年平均 2.31 出版当年[2017版] 2.356 出版当年五年平均 2.011 出版前一年[2016版] 2.625 出版后一年[2018版]

第一作者：

第一作者机构： [1]Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University

共同第一作者：

通讯作者：

通讯机构： [5]Department of Orthodontics, School of Stomatology, Capital Medical University [*1]Department of Orthodontics, School of Stomatology Capital Medical University, Tian Tan Xi Li No.4, Beijing 100050, P. R. China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Comparative Study of 660 and 830 nm Photobiomodulation in Promoting Orthodontic Tooth Movement [2]microRNA-21 and hypertension [3]人参皂甙Rb1调节microRNA-21保护心肌细胞的作用 [4]Topology Optimization Driven Bone-Remodeling Simulation for Lumbar Interbody Fusion [5]Granulocyte Colony-Stimulating Factor Induces Osteoblast Inhibition by B Lymphocytes and Osteoclast Activation by T Lymphocytes during Hematopoietic Stem/Progenitor Cell Mobilization [6]MicroRNA-146a and-21 cooperate to regulate vascular smooth muscle cell proliferation via modulation of the Notch signaling pathway [7]Cisplatin Nanoparticles Promote Intratumoral CD8+ T Cell Priming via Antigen Presentation and T Cell Receptor Crosstalk. [8]MicroRNA-21 promotes wound healing via the Smad7-Smad2/3-Elastin pathway [9]Effect of low-dose X-ray irradiation and Ti particles on the osseointegration of prosthetic [10]不同T细胞亚群T细胞受体删除环含量的评价