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YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway

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资源类型：

收录情况： ◇ SCIE

作者：
Liu, H[] * ; Mei, D[] ; Xu, P[] ; Wang, H[] ; Wang, Y[] ;
机构： [a]Department of Pharmacy, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China [b]Department of Pharmaceutical Engineering, College of Pharmacy, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010110, China [c]Department of Gastrointestinal Surgery, China-Japan Friendship Hospital, 2 Yinghua Road, Beijing, 100029, China
出处：
DOI： 10.3892/ol.2019.11049
ISSN：

关键词： Endoplasmic reticulum stress ERK Gastric cancer Yes-associated protein

摘要：
Yes-associated protein (YAP) has been reported to serve an important role in gastric cancer cell survival and migration. However, the underlying mechanism remains unclear. The aim of present study was to identify the underlying mechanism through which Yap sustains gastric cancer viability and migration. The results of the present study demonstrated that YAP expression was upregulated in gastric cancer MKN-28/74 cells compared with normal gastric GES-1 cells. Functional studies revealed that silencing of YAP inhibited gastric cancer MKN-28/74 cell viability and invasion. Mechanistically, YAP may promote gastric cancer cell survival and migration/invasion by inhibiting the endoplasmic reticulum (ER) stress pathway. In addition, YAP may regulate ER stress by activating the ERK signaling pathway. The results of the present study suggested that YAP may be a tumor promoter in gastric cancer and act through the ERK/ER stress pathway; therefore, YAP may have potential implications for new approaches to gastric cancer therapy. © 2019 Spandidos Publications. All rights reserved.

基金：
This work was supported in part by Inner Mongolia Autonomous Region Natural Science Foundation (grant no., 2016MS0847), Scientific Research Planning Project of Health and Family Planning Commission of Inner Mongolia Autonomous Region (grant no., 201701048) and Science and Technology Innovation Guidance Project of Inner Mongolia Autonomous Region (grant no., KCBJ2018021).
语种：
外文
中科院(CAS)分区：
出版当年[2018]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
JCR分区：
出版当年[2017]版：
Q4 ONCOLOGY
最新[2023]版：
Q3 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
推荐引用方式(GB/T 7714)：
Liu H,Mei D,Xu P,et al.YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway[J].ONCOLOGY LETTERS.2019,18(6):doi:10.3892/ol.2019.11049.
APA：
Liu, H,Mei, D,Xu, P,Wang, H&Wang, Y.(2019).YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway.ONCOLOGY LETTERS,18,(6)
MLA：
Liu, H,et al."YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway".ONCOLOGY LETTERS 18..6(2019)

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