详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Advances in Normobaric Hyperoxia Brain Protection in Experimental Stroke.

文献详情

资源类型：

WOS体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Department of Neurosurgery,School of Medicine, Wayne State University, Detroit, MI, United States [3]Department of Neurosurgery, Xuanwu Hospital,Capital Medical University, Beijing, China [4]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China

出处：

DOI：

ISSN：

关键词： normobaric hyperoxia experimental stroke brain trauma protection hyperbaric oxygen

摘要：

As we all know that stroke is still a leading cause of death and acquired disability. Etiological treatment and brain protection are equally important. This review aimed to summarize the advance of normobaric-hyperoxia (NBHO) on brain protection in the setting of experimental stroke and brain trauma. We analyzed the data from relevant studies published on PubMed Central (PMC) and EMBASE, about NBHO on brain protection in the setting of experimental ischemic and hemorrhagic strokes and brain trauma, which revealed that NBHO had important value on improving hypoxia and attenuating ischemia damage. The mechanisms of NBHO involved increasing the content of oxygen in brain tissues, restoring the function of mitochondria, enhancing the metabolism of neurons, alleviating blood-brain barrier (BBB) damage, weakening brain cell edema, reducing intracranial pressure, and improving cerebral blood flow, especially in the surrounding of injured area of the brain, to make the neurons in penumbral area alive. Compared to hyperbaric oxygen (HBO), NBHO is more safe and more easily to transform to clinical use, whereby, further studies about the safety and efficacy as well as the proper treatment protocol of NBHO on human may be still needed. Copyright © 2020 Chen, Ding, Ji and Meng.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

JCR分区：

出版当年[2018]版：

Q3 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 3.3 最新五年平均 2.635 出版当年[2018版] 3.233 出版当年五年平均 3.508 出版前一年[2017版] 2.889 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China

通讯作者：

通讯机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [4]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Normobaric Hyperoxia Stabilizing Ischemic Penumbra [2]Normobaric Hyperoxia Combined With Reperfusion for Acute Ischemic Stroke [3]Normobaric Hyperoxia Extends Neuro- and Vaso-Protection of N-Acetylcysteine in Transient Focal Ischemia [4]Normobaric Hyperoxia Combined With Endovascular Treatment for Acute Ischemic Stroke [5]Reduction of zinc accumulation in mitochondria contributes to decreased cerebral ischemic injury by normobaric hyperoxia treatment in an experimental stroke model [6]Normobaric Hyperoxia Combined With Endovascular Treatment in Acute Ischemic Stroke (OPENS-2) [7]Enhancing Blood-Brain Barrier Integrity in Patients With Acute Ischemic Stroke Via Normobaric Hyperoxia [8]Hyperbaric oxygen therapy sensitizes nimustine treatment for glioma in mice [9]Hyperbaric oxygen treatment of spinal cord injury in rat model [10]Normobaric hyperoxia-based neuroprotective therapies in ischemic stroke.