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Morroniside enhances angiogenesis and improves cardiac function following acute myocardial infarction in rats.

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收录情况： ◇ SCIE

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机构： [1]Department of Experimental Animal Center, Xuanwu Hospital of Capital Medical University, Beijing, 100053, PR China [2]Department of Pharmacy, Zunyi Medical University, Guizhou, 563000, PR China [3]Beijing Institute for Brain Disorders, Beijing, 100069, PR China

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关键词： Morroniside Acute myocardial infarction Angiogenesis Cardiac function VEGF/VEGF receptor 2 signaling pathway

摘要：

Angiogenesis is critical for re-establishing blood supply to the ischemic myocardium after acute myocardial infarction (AMI). This study aimed to investigate the effects of morroniside on angiogenesis after AMI and explored associated proangiogenic mechanisms. A rat model of AMI was established by ligation of the left anterior descending coronary artery followed by administration of three doses of morroniside. Immunofluorescence staining was performed to identify newly generated endothelial cells and arterioles. The protein expression levels associated with angiogenesis were examined by western blots. Echocardiography was used to examine cardiac function. Our data revealed that morroniside promoted angiogenesis and improved cardiac function in rats with AMI. The proangiogenic effect of morroniside might be mediated by the VEGFA/VEGF receptor 2 signaling pathway. Copyright © 2020 Elsevier B.V. All rights reserved.

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出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区药学

最新[2023]版：

大类 | 3 区医学

小类 | 2 区药学

JCR分区：

出版当年[2018]版：

Q2 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.2 最新[2023版] 4.3 最新五年平均 3.17 出版当年[2018版] 3.12 出版当年五年平均 3.04 出版前一年[2017版] 3.263 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Experimental Animal Center, Xuanwu Hospital of Capital Medical University, Beijing, 100053, PR China

通讯作者：

通讯机构： [1]Department of Experimental Animal Center, Xuanwu Hospital of Capital Medical University, Beijing, 100053, PR China [3]Beijing Institute for Brain Disorders, Beijing, 100069, PR China [*1]Department of Experimental Animal Center, Xuanwu Hospital of Capital Medical University, Beijing, 100053, PR China

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