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Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function.

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机构： [1]Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Center of Epilepsy, Center for Brain Disorders Research, Capital Medical University, Beijing, China. [3]Center of Epilepsy, Beijing Institute of Brain Disorders, Beijing, China. [4]Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China. [5]Department of Functional Neurosurgery, Beijing Children's Hospital, Capital Medical University, Beijing, China. [6]Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

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关键词： epilepsy NKCC1 KCC2 electrophysiology bumetanide

摘要：

As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl-) flow, which relies on the intracellular chloride concentration ([Cl-]i) of the postsynaptic neuron. The Na-K-2Cl cotransporter isoform 1 (NKCC1) and the K-Cl cotransporter isoform 2 (KCC2) are two main cation-chloride cotransporters (CCCs) that have been implicated in human epilepsy. NKCC1 and KCC2 reset [Cl-]i by accumulating and extruding Cl-, respectively. Previous studies have shown that the profile of NKCC1 and KCC2 in neonatal neurons may reappear in mature neurons under some pathophysiological conditions, such as epilepsy. Although increasing studies focusing on the expression of NKCC1 and KCC2 have suggested that impaired chloride plasticity may be closely related to epilepsy, additional neuroelectrophysiological research aimed at studying the functions of NKCC1 and KCC2 are needed to understand the exact mechanism by which they induce epileptogenesis. In this review, we aim to briefly summarize the current researches surrounding the expression and function of NKCC1 and KCC2 in epileptogenesis and its implications on the treatment of epilepsy. We will also explore the potential for NKCC1 and KCC2 to be therapeutic targets for the development of novel antiepileptic drugs. Copyright © 2020 Liu, Wang, Liang, Zhang and Yang.

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基金编号： 81971202 81671367 81790653 81471391

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出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

JCR分区：

出版当年[2018]版：

Q3 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 3.3 最新五年平均 2.635 出版当年[2018版] 3.233 出版当年五年平均 3.508 出版前一年[2017版] 2.889 出版后一年[2019版]

第一作者：

第一作者机构： [1]Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Center of Epilepsy, Center for Brain Disorders Research, Capital Medical University, Beijing, China. [3]Center of Epilepsy, Beijing Institute of Brain Disorders, Beijing, China. [4]Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.

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