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Increased Preoperative Plasma Level of Microbial 16S rDNA Translocation Is Associated With Relapse After Prostatectomy in Prostate Cancer Patients.

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收录情况： ◇ SCIE

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机构： [1]Department of Urology, Capital Medical University Affiliated XuanWu Hospital, Beijing, China. [2]State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University, Changsha, China. [3]Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, United States. [4]Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States. [5]CAS Key Laboratory of Pathogenic Microbiology and Immunology, Beijing Key Laboratory of Antimicrobial Resistance and Pathogen Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. [6]Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China. [7]Department of Pathogenic Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China. [8]Division of Hematology and Oncology, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States. [9]Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States.

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关键词： prostate cancer microbial translocation prostatectomy relapse prostate-specific antigen

摘要：

Background: The environmental factors for promoting prostate cancer (PCa) recurrence remain unknown. Methods: A retrospective cross-sectional study was conducted in healthy men (n = 12) and PCa patients undergoing prostatectomy (n = 27). Plasma preoperative level of total cell-free bacterial 16S rDNA, a marker of microbial translocation, was evaluated by qPCR. Plasma levels of prostate-specific antigen (PSA) were evaluated by ELISA. Results: Similar degrees of microbial translocation were found in healthy men and patients. However, the levels of microbial 16S rDNA were increased in patients with cancer relapse (n = 10) compared to patients without relapse (n = 17) after prostatectomy. Furthermore, the levels of microbial 16S rDNA were marginally increased in patients with pT3 or pT4 tumors compared to those with pT 2 or less. The levels of microbial 16S rDNA tended to increase in patients with higher pathologic tumor stage, Gleason score, and margin and lymph node involvements; but these differences did not reach significance. Conclusion: The plasma 16S rDNA levels increased in patients with PCa who have biochemical recurrence and 16S rDNA levels were higher in patients with higher-grade PCa. Copyright © 2020 Ou, Zhou, Turner, Zhu, Lilly and Jiang.

基金：

基金编号： IRG-16-185-17 W81XWH-15-10696 2018ZX1021-001 R21CA194469 U54CA210961

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出版当年[2019]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

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出版当年[2018]版：

Q2 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 3.5 最新[2023版] 4 最新五年平均 4.137 出版当年[2018版] 0 出版当年五年平均 4.416 出版前一年[2017版] 4.848 出版后一年[2019版]

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第一作者机构： [1]Department of Urology, Capital Medical University Affiliated XuanWu Hospital, Beijing, China.

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Increased Preoperative Plasma Level of Microbial 16S rDNA Translocation Is Associated With Relapse After Prostatectomy in Prostate Cancer Patients.

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