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Different nasopharynx and oropharynx microbiota imbalance in children with Mycoplasma pneumoniae or influenza virus infection

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资源类型：
作者：
Qian Zhou[b] * ; Gan Xie[a,c] * ; Yanhong Liu[d] ; Heping Wang[a] ; Yonghong Yang[a,c,d] ; Kunling Shen[a,c] ; Wenkui Dai[d] ; Shuaicheng Li[b] ; Yuejie Zheng[a] ;
机构： [a]Department of Respiratory Diseases, Shenzhen Children's Hospital, No. 7019, Yitian Road, Futian District, Shenzhen, 518026, China [b]Department of Computer Science, City University of Hong Kong, No. 83 Tat Chee Avenue Kowloon, Hong Kong, 999077, China [c]Department of Respiratory Diseases, Beijing Children's Hospital Affiliated to Capital Medical University, No. 56 Nan-li-shi Road, Beijing, 100045, China [d]Department of Microbial Research, WeHealthGene, No. 2-10, Jinlong Road, Pingshan District, Shenzhen, 518118, China
出处：
DOI： 10.1016/j.micpath.2020.104189
ISSN：

关键词： Influenza Microbiota Mycoplasma pneumoniae pneumonia Nasopharynx Oropharynx

摘要：
Background: The Mycoplasma pneumoniae(MP) and influenza virus are two common pathogens causing pediatric acute respiratory tract infection. Though emerging reports demonstrated imbalanced respiratory microbiota in respiratory infection, the respiratory microbiota differences between MP and influenza virus remained to be explored. Methods: We collected paired nasopharyngeal(NP) and oropharyngeal(OP) microbial samples from 165 children, including 40 patients with MP pneumonia, 66 patients with influenza virus infection and 59 age-matched healthy children. Results: The NP and OP microbial diversity decreased in MP infection and increased in influenza infection as compared to healthy children. The Staphylococcus dominated Mycoplasma pneumoniae pneumonia(MPP) patients’ NP microbiota while five representative patterns remained in influenza patients. In OP microbiota, Streptococcus significantly enriched in MPP group and decreased in Influenza group. Decision tree analysis indicated that Ralstonia and Acidobacteria could discriminate microbial samples in healthy (59/67), MP (35/38) and Influenza groups (55/60) with high accuracy. Conclusions: This study revealed that dominant bacterial structure in the airway was niche- and disease-specific. It could facilitate the stratification of respiratory microbial samples with different infectious agents. © 2020

基金：
This work was supported by the Guangdong Medical Research Fund [ A2016501 to Y.Z.], Sanming Project of Medicine in Shenzhen [ SZSM201512030 to Y.Z.], and Shenzhen Science and Technology Project [ JCYJ20170303155012371 to H.W].
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 3 区 医学
小类 | 4 区 免疫学 4 区 微生物学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 免疫学 3 区 微生物学
第一作者：
第一作者机构： [b]Department of Computer Science, City University of Hong Kong, No. 83 Tat Chee Avenue Kowloon, Hong Kong, 999077, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Qian Zhou,Gan Xie,Yanhong Liu,et al.Different nasopharynx and oropharynx microbiota imbalance in children with Mycoplasma pneumoniae or influenza virus infection[J].Microbial pathogenesis.2020,144:104189.doi:10.1016/j.micpath.2020.104189.
APA：
Qian Zhou,Gan Xie,Yanhong Liu,Heping Wang,Yonghong Yang...&Yuejie Zheng.(2020).Different nasopharynx and oropharynx microbiota imbalance in children with Mycoplasma pneumoniae or influenza virus infection.Microbial pathogenesis,144,
MLA：
Qian Zhou,et al."Different nasopharynx and oropharynx microbiota imbalance in children with Mycoplasma pneumoniae or influenza virus infection".Microbial pathogenesis 144.(2020):104189

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