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Oligosaccharide attenuates aging-related liver dysfunction by activating Nrf2 antioxidant signaling

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收录情况： ◇ SCIE

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机构： [1]Department of Anatomy, School of Basic Medicine, Binzhou Medical University, Yantai, China [2]Department of Pathology, Xuanwu Hospital, Capital Medical University, Beiing, China [3]Department of Immunology, School of Basic Medicine, Binzhou Medical University, Yantai, China

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关键词： anti-aging chitosan oligosaccharide D-galactose liver Nrf2 pathway

摘要：

Chitosan oligosaccharide (COS) is the depolymerized product of chitosan possessing various biological activities and protective effects against inflammation and oxidative injury. The aim of the present study was to investigate the antioxidant effects of COS supplements on aging-related liver dysfunction. We found that COS treatment significantly attenuated elevated liver function biomarkers and oxidative stress biomarkers and decreased antioxidative enzyme activities in liver tissues in D-galactose (D-gal)-treated mice. Furthermore, COS treatment significantly upregulated the expression of Nrf2 and its downstream target genes HO-1, NQO1, and CAT. Moreover, in vitro experiments showed that COS treatment played a vital role in protecting H2O2-exposed L02 cells against oxidative stress by activating Nrf2 antioxidant signaling. These data indicate that COS could protect against D-gal-induced hepatic aging by activating Nrf2 antioxidant signaling, which may provide novel applications for the prevention and treatment of aging-related hepatic dysfunction.

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出版当年[2019]版：

大类 | 4 区工程技术

小类 | 4 区食品科技

最新[2023]版：

大类 | 2 区农林科学

小类 | 3 区食品科技

JCR分区：

出版当年[2018]版：

Q2 FOOD SCIENCE & TECHNOLOGY

最新[2023]版：

Q2 FOOD SCIENCE & TECHNOLOGY

影响因子： 3.5 最新[2023版] 4.2 最新五年平均 1.747 出版当年[2018版] 0 出版当年五年平均 1.521 出版前一年[2017版] 1.797 出版后一年[2019版]

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第一作者机构： [1]Department of Anatomy, School of Basic Medicine, Binzhou Medical University, Yantai, China

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通讯机构： [*1]Department of Anatomy, School of Basic Medicine, Binzhou Medical University, Yantai, Shandong Province 264003, China [*2]Department of Immunology, School of Basic Medicine, Binzhou Medical University, Yantai, Shandong Province 264003, China

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