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Elevated plasma S100B concentration is associated with mesial temporal lobe epilepsy in Han Chinese: A case-control study

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机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China [2]Capital Med Univ, Tongren Hosp, Dept Neurol, Beijing 100730, Peoples R China [3]Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China [4]Natl Univ Singapore, Dept Psychol Med, Yong Loo Lin Sch Med, Singapore 117548, Singapore
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关键词: Mesial temporal lobe epilepsy S100B Gliosis Hippocampal sclerosis Gender Intelligence quotient

摘要:
Mesial temporal lobe epilepsy (MTLE) is a common type of intractable epilepsy characterized by astroglial gliosis. The S100B was viewed as an astrocyte marker and experimental studies indicated that S100B might be involved in the pathophysiology of temporal lobe epilepsy. In this study, we measured plasma S100B levels by ELISA in 28 patients with MTLE and 28 healthy controls and found that patients showed significantly elevated S100B levels compared with healthy controls (P = 0.018). Moreover, S100B levels were significantly higher in female patients than those in male patients (P = 0.027). These results suggest that S100B may be a biomarker of MTLE. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

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出版当年[2009]版:
大类 | 3 区 医学
小类 | 4 区 神经科学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 神经科学
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出版当年[2008]版:
Q3 NEUROSCIENCES
最新[2023]版:
Q3 NEUROSCIENCES

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第一作者机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China [2]Capital Med Univ, Tongren Hosp, Dept Neurol, Beijing 100730, Peoples R China
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通讯机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China [*1]Capital Med Univ, Xuanwu Hosp, Dept Neurol, 45 Chang Chun St, Beijing 100053, Peoples R China
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