机构:[1]State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center forCardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShiRoad 167, Beijing 100037, China.[2]Department of Cardiology, Xuanwu Hospital, Capital MedicalUniversity, Beijing, China内科系统心脏科(内科专业)首都医科大学宣武医院[3]Department of Cardiology, Beijing Anzhen Hospital, Capital MedicalUniversity, Beijing, China首都医科大学附属安贞医院[4]Heart Institute (InCor) University of Sao Paulo Medical School Hospital, SaoPaulo, Brazil[5]Hospital Israelita Albert Einstein, Sao Paulo, Brazil
Triglyceride-rich lipoproteins (TRL)-related biomarkers, including TRL-cholesterol (TRL-C), remnant-like lipoprotein particles cholesterol (RLP-C) and apolipoprotein C-III (apoC-III), have been associated with atherosclerosis. However, their prognostic values have not been fully determined, especially in patients with previous coronary artery disease (CAD). This study aimed to examine the associations of TRL-C, RLP-C and apoC-III with incident cardiovascular events (CVEs) in the setting of secondary prevention of CAD. Plasma TRL-C, RLP-C and total apoC-III were directly measured. A total of 4355 participants with angiographically confirmed CAD were followed-up for the occurrence of CVEs. During a median follow-up period of 5.1 (IQR: 3.9-6.4) years, 543 (12.5%) events occurred. Patients with incident CVEs had significantly higher levels of TRL-C, RLP-C and apoC-III than those without events. Multivariable Cox analysis indicated that a log unit increase in TRL-C, RLP-C and apoC-III increased the risk of CVEs by 49% (95%CI: 1.16-1.93), 21% (95%CI: 1.09-1.35) and 40% (95%CI: 1.11-1.77), respectively. High TRL-C, RLP-C and apoC-III were also independent predictors of CVEs in individuals with low-density lipoprotein cholesterol levels ≤1.8 mmol/L (n=1068). The addition of RLP-C level to a prediction model resulted in a significant increase in discrimination and all three TRL biomarkers improved risk reclassification. Thus, TRL-C, RLP-C, and apoC-III levels were independently associated with incident CVEs in Chinese CAD patients undergoing statin therapy..
基金:
the Capital Health Development Fund (201614035) and CAMS Major Collaborative Innovation Project (2016-I2M-1-011). RDS is a recipient of a scholarship from the Conselho Nacional de Pesquisa e Desenvolvimento Tecnologico (CNPq) process # 303734/2018-3, Brazil.
第一作者机构:[1]State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center forCardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShiRoad 167, Beijing 100037, China.
Ye-Xuan Cao,Hui-Wen Zhang,Jing-Lu Jin,et al.Prognostic utility of triglyceride-rich lipoproteins-related markers in patients with coronary artery disease.[J].JOURNAL OF LIPID RESEARCH.2020,61(9):1254-1262.doi:10.1194/jlr.RA120000746.
APA:
Ye-Xuan Cao,Hui-Wen Zhang,Jing-Lu Jin,Hui-Hui Liu,Yan Zhang...&Jian-Jun Li.(2020).Prognostic utility of triglyceride-rich lipoproteins-related markers in patients with coronary artery disease..JOURNAL OF LIPID RESEARCH,61,(9)
MLA:
Ye-Xuan Cao,et al."Prognostic utility of triglyceride-rich lipoproteins-related markers in patients with coronary artery disease.".JOURNAL OF LIPID RESEARCH 61..9(2020):1254-1262