Combining Visual Rating Scales for Medial Temporal Lobe Atrophy and Posterior Atrophy to Identify Amnestic Mild Cognitive Impairment from Cognitively Normal Older Adults: Evidence Based on Two Cohorts.
机构：[a]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[b]Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China[c]Department of Neurology, the First Hospital of Tsinghua University, Beijing, China[d]Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA[e]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China[f]National Clinical Research Center for Geriatric Disorders, Beijing, China
Visual rating scales for medial temporal lobe atrophy (MTA) and posterior atrophy (PA) have been reported to be useful for Alzheimer's disease diagnosis in routine clinical practice.
To investigate the efficacy of combined MTA and PA visual rating scales to discriminate amnestic mild cognitive impairment (aMCI) patients from healthy controls.
This study included T1-weighted MRI images from two different cohorts. In the first cohort, we recruited 73 patients with aMCI and 48 group-matched cognitively normal controls for training and validation. Visual assessments of MTA and PA were carried out for each participant. Global gray matter volume and density were estimated using voxel-based morphometry analysis as the objective reference. We investigated the discriminative power of a single visual rating scale and the combination of the MTA and PA rating scales for identifying aMCI. The second cohort, consisting of 33 aMCI patients and 45 controls, was used to verify the reliability of the visual assessments.
Compared with the single visual rating scale, the combination of the MTA and PA exhibited the best discriminative power, with an AUC of 0.818±0.041, which was similar to the diagnostic accuracy of the gray matter volumetric measures. The discriminative power of the combined MTA and PA was verified in the second cohort (AUC 0.824±0.058).
The combined MTA and PA rating scales demonstrated practical diagnostic value for distinguishing aMCI patients from controls, suggesting its potential to serve as a convenient and reproducible method to assess the degree of atrophy in clinical settings.
第一作者机构：[a]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.[*2]Shanghai Institute for Advanced Communication and Data Science, Shanghai University, 99 Shangda Road, Shanghai 200444, China
推荐引用方式(GB/T 7714)：
Sheng Can,Sun Yu,Wang Min,et al.Combining Visual Rating Scales for Medial Temporal Lobe Atrophy and Posterior Atrophy to Identify Amnestic Mild Cognitive Impairment from Cognitively Normal Older Adults: Evidence Based on Two Cohorts.[J].JOURNAL OF ALZHEIMERS DISEASE.2020,77(1):323-337.doi:10.3233/JAD-200016.
APA：
Sheng Can,Sun Yu,Wang Min,Wang Xiaoni,Liu Yi...&Han Ying.(2020).Combining Visual Rating Scales for Medial Temporal Lobe Atrophy and Posterior Atrophy to Identify Amnestic Mild Cognitive Impairment from Cognitively Normal Older Adults: Evidence Based on Two Cohorts..JOURNAL OF ALZHEIMERS DISEASE,77,(1)
MLA：
Sheng Can,et al."Combining Visual Rating Scales for Medial Temporal Lobe Atrophy and Posterior Atrophy to Identify Amnestic Mild Cognitive Impairment from Cognitively Normal Older Adults: Evidence Based on Two Cohorts.".JOURNAL OF ALZHEIMERS DISEASE 77..1(2020):323-337
