机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[2]China National Clinical Research Center for Neurological Diseases, Beijing, China,[3]College of Electrical and Control Engineering, North China University of Technology, Beijing, China,[4]Laboratory of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Ministry of Science and Technology, Beijing, China,[5]Department of Functional Neurosurgery, Beijing Haidian Hospital, Beijing, China,[6]Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China,[7]Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China
High-frequency oscillations (HFOs) have been proposed as a promising biomarker of the epileptogenic zone (EZ). But accurate delineation of EZ based on HFOs is still challenging. Our study compared HFOs from EZ and non-EZ on the basis of their associations with interictal slow waves, aiming at exploring a new way to localize EZ. Nineteen medically intractable epilepsy patients with good surgical outcome were included. Five minute interictal intracranial electroencephalography (EEG) epochs of slow-wave sleep were randomly selected; then ripples (80-200 Hz), fast ripples (FRs; 200-500 Hz), and slow waves (0.1-4 Hz) were automatically analyzed. The EZ and non-EZ were identified by resection range during the surgeries. We found that both ripples and FRs superimposed more frequently on slow waves in EZ than in non-EZ (P< 0.01). Although ripples preferred to occur on the down state of slow waves in both two groups, ripples in EZ tended to be closer to the down-state peak of slow wave than in non-EZ (-174 vs. -231 ms,P= 0.008). As for FR, no statistical difference was found between the two groups (P= 0.430). Additionally, slow wave-containing ripples in EZ had a steeper slope (1.7 vs. 1.5 mu V/ms,P< 0.001) and wider distribution ratio (32.3 vs. 30.1%,P< 0.001) than those in the non-EZ. But for slow wave-containing FR, only a steeper slope (1.7 vs. 1.4 mu V/ms,P< 0.001) was observed. Our study innovatively compared the different features of association between HFOs and slow wave in EZ and non-EZ from refractory focal epilepsy with good surgical outcome, proposing a new method to localize EZ and facilitating the surgical plan.
基金：
The study was financially supported by the National Natural
Science Foundation of China (81801280 to GR, 61803003 to
JY, 81601126 to JR, and 81971202 to XY), Youth Research
Fund of Beijing Tiantan Hospital affiliated to Capital Medical University (2017-YQN-01 to GR), Capital Health Research and
Development of Special grant (2016-1-2011 and 2020-1-2013
to QW), Beijing-Tianjin-Hebei Cooperative Basic Research
Program (H2018206435 to QW), and the National Key R&D
Program of China grant (2017YFC1307500 to QW).
第一作者机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[2]China National Clinical Research Center for Neurological Diseases, Beijing, China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Guoping Ren,Jiaqing Yan,Yueqian Sun,et al.Association Between Interictal High-Frequency Oscillations and Slow Wave in Refractory Focal Epilepsy With Good Surgical Outcome[J].FRONTIERS IN HUMAN NEUROSCIENCE.2020,14:doi:10.3389/fnhum.2020.00335.
APA：
Guoping Ren,Jiaqing Yan,Yueqian Sun,Jiechuan Ren,Jindong Dai...&Qun Wang.(2020).Association Between Interictal High-Frequency Oscillations and Slow Wave in Refractory Focal Epilepsy With Good Surgical Outcome.FRONTIERS IN HUMAN NEUROSCIENCE,14,
MLA：
Guoping Ren,et al."Association Between Interictal High-Frequency Oscillations and Slow Wave in Refractory Focal Epilepsy With Good Surgical Outcome".FRONTIERS IN HUMAN NEUROSCIENCE 14.(2020)
