机构：[a]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院[b]Beijing Key Laboratory of Neuromodulation, Beijing 100053, China[c]Department of Functional Neurology, Lu He Hospital, Capital Medical University, Beijing 101149, China[d]Beijing Institute of Functional Neurosurgery, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China神经外科首都医科大学宣武医院[e]Department of Functional Neurosurgery, Lu He Hospital, Capital Medical University, Beijing 101149, China
Objective: In some cases of single focus epilepsy, conventional video electroencephalography (EEG) cannot reveal the epileptogenic focus even when intracranial electrodes are used. Here, we tested whether analyzing high frequency oscillations (HFOs) can be used to determine the ictal onset zone in suspected bitemporal epilepsy and improve seizure outcome. Methods: We prospectively studied 13 patients with refractory temporal seizures who were treated over a 4-year period and underwent bilateral placement of intracranial electrodes. Subdural strips were used in all cases, and depth electrodes were implanted into mesial temporal lobes in 10 patients. The mean patient age was 30.92 years, and 30.7% of patients were male. Patients were monitored by conventional and wide-band frequency amplifiers. Results: Conventional invasive EEG monitoring of interictal periods showed bilateral epileptiform abnormalities in 12 patients (92.3%) and unilateral epileptiform abnormalities in one (7.7%), and monitoring of ictal periods revealed unilateral seizure origins in nine patients (69.2%) and bilateral origins in four ( 30.8%). In contrast, high frequency invasive EEG monitoring of interictal periods showed bilateral HFOs in seven patients (53.8%) and unilateral HFOs in six (46.2%), and monitoring of ictal periods revealed unilateral HFOs in all 10 patients who were tested. Three patients were not monitored during ictal periods because of time limitations. All 13 patients subsequently underwent a standard unilateral temporal lobectomy and have been followed-up for a minimum of 12 months. Eleven (84%) had a Class I outcome, one (8%) a Class II outcome, and one a Class III outcome. Significance: Bilateral placement of subdural strip and depth electrodes for seizure monitoring in patients with suspected bitemporal epilepsy is both safe and effective. Monitoring high frequency oscillations can help determine the laterality of the onset zone when localization using conventional EEG or brain MRI fails. (C) 2016 Elsevier B.V. All rights reserved.
基金：
National High-tech R&D Pro-gram (863 Program), code: 2015AA020514;
Beijing MunicipalScience and Technology Project (No.Z121107001012007 andZ131107002813039);
Beijing Municipal Administration of Hospi-tals Clinical Medicine Development for special funding support,code: XM201401.
第一作者机构：[a]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China[b]Beijing Key Laboratory of Neuromodulation, Beijing 100053, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, Xuan Wu Hospital, CapitalMedical University, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Chunyan Liu,Ruihua Zhang,Guojun Zhang,et al.High frequency oscillations for lateralizing suspected bitemporal epilepsy[J].EPILEPSY RESEARCH.2016,127:233-240.doi:10.1016/j.eplepsyres.2016.09.006.
APA：
Chunyan Liu,Ruihua Zhang,Guojun Zhang,Tao Yu,Junli Tai...&Yuping Wang.(2016).High frequency oscillations for lateralizing suspected bitemporal epilepsy.EPILEPSY RESEARCH,127,
MLA：
Chunyan Liu,et al."High frequency oscillations for lateralizing suspected bitemporal epilepsy".EPILEPSY RESEARCH 127.(2016):233-240
