机构:[1]Neuroelectrophysiological Laboratory Xuanwu Hospital, Capital Medical University, Beijing, P. R. China首都医科大学宣武医院[2]Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, P. R. China[3]College of Electrical and Control Engineering North China University of Technology, Beijing, P. R. China[4]Functional Neurology and Neurosurgery Beijing Haidian Hospital, Beijing, P. R. China[5]State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research Beijing Normal University, Beijing, P. R. China[6]Center for Collaboration and Innovation in Brain and Learning Sciences Beijing Normal University, Beijing, P. R. China[7]Department of Neruology, Beijing Children’s Hospital Capital Medical University, Beijing, P. R. China
High frequency oscillations (HFOs) are considered as biomarker for epileptogenicity. Reliable automation of HFOs detection is necessary for rapid and objective analysis, and is determined by accurate computation of the baseline. Although most existing automated detectors measure baseline accurately in channels with rare HFOs, they lose accuracy in channels with frequent HFOs. Here, we proposed a novel algorithm using the maximum distributed peak points method to improve baseline determination accuracy in channels with wide HFOs activity ranges and calculate a dynamic baseline. Interictal ripples (80-200 Hz), fast ripples (FRs, 200-500 Hz) and baselines in intracerebral EEGs from seven patients with intractable epilepsy were identified by experienced reviewers and by our computer-automated program, and the results were compared. We also compared the performance of our detector to four well-known detectors integrated in RIPPLELAB. The sensitivity and specificity of our detector were, respectively, 71% and 75% for ripples and 66% and 84% for FRs. Spearman's rank correlation coefficient comparing automated and manual detection was 0.896 +/- 0.080 for ripples and 0.974 +/- 0.030 for FRs (p < 0.01). In comparison to other detectors, our detector had a relatively higher sensitivity and specificity. In conclusion, our automated detector is able to accurately calculate a dynamic iEEG baseline in different HFO activity channels using the maximum distributed peak points method, resulting in higher sensitivity and specificity than other available HFO detectors.
基金:
the National Natural Science Foundation of China (81471391 and 81671367),
the Natural Science Foundation of Beijing (11622308),
the Beijing Institute for Brain Disorders Foundation (BIBDPXM2014 014226 000016),
the Prevention, Collaboration and Innovation Center for Brain Disorders Foundation (PXM2015 014226 000051).
第一作者机构:[1]Neuroelectrophysiological Laboratory Xuanwu Hospital, Capital Medical University, Beijing, P. R. China[2]Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, P. R. China
通讯作者:
通讯机构:[4]Functional Neurology and Neurosurgery Beijing Haidian Hospital, Beijing, P. R. China[7]Department of Neruology, Beijing Children’s Hospital Capital Medical University, Beijing, P. R. China
推荐引用方式(GB/T 7714):
Guo-Ping Ren,Jia-Qing Yan,Zhi-Xin Yu,et al.Automated Detector of High Frequency Oscillations in Epilepsy Based on Maximum Distributed Peak Points[J].INTERNATIONAL JOURNAL OF NEURAL SYSTEMS.2018,28(1):1750029.doi:10.1142/S0129065717500290.
APA:
Guo-Ping Ren,Jia-Qing Yan,Zhi-Xin Yu,Dan Wang,Xiao-Nan Li...&Xiao-Fei Wang.(2018).Automated Detector of High Frequency Oscillations in Epilepsy Based on Maximum Distributed Peak Points.INTERNATIONAL JOURNAL OF NEURAL SYSTEMS,28,(1)
MLA:
Guo-Ping Ren,et al."Automated Detector of High Frequency Oscillations in Epilepsy Based on Maximum Distributed Peak Points".INTERNATIONAL JOURNAL OF NEURAL SYSTEMS 28..1(2018):1750029