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Automated Detector of High Frequency Oscillations in Epilepsy Based on Maximum Distributed Peak Points

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机构: [1]Neuroelectrophysiological Laboratory Xuanwu Hospital, Capital Medical University, Beijing, P. R. China [2]Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, P. R. China [3]College of Electrical and Control Engineering North China University of Technology, Beijing, P. R. China [4]Functional Neurology and Neurosurgery Beijing Haidian Hospital, Beijing, P. R. China [5]State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research Beijing Normal University, Beijing, P. R. China [6]Center for Collaboration and Innovation in Brain and Learning Sciences Beijing Normal University, Beijing, P. R. China [7]Department of Neruology, Beijing Children’s Hospital Capital Medical University, Beijing, P. R. China
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关键词: High frequency oscillations automated detector maximum distributed peak points epilepsy dynamic baseline

摘要:
High frequency oscillations (HFOs) are considered as biomarker for epileptogenicity. Reliable automation of HFOs detection is necessary for rapid and objective analysis, and is determined by accurate computation of the baseline. Although most existing automated detectors measure baseline accurately in channels with rare HFOs, they lose accuracy in channels with frequent HFOs. Here, we proposed a novel algorithm using the maximum distributed peak points method to improve baseline determination accuracy in channels with wide HFOs activity ranges and calculate a dynamic baseline. Interictal ripples (80-200 Hz), fast ripples (FRs, 200-500 Hz) and baselines in intracerebral EEGs from seven patients with intractable epilepsy were identified by experienced reviewers and by our computer-automated program, and the results were compared. We also compared the performance of our detector to four well-known detectors integrated in RIPPLELAB. The sensitivity and specificity of our detector were, respectively, 71% and 75% for ripples and 66% and 84% for FRs. Spearman's rank correlation coefficient comparing automated and manual detection was 0.896 +/- 0.080 for ripples and 0.974 +/- 0.030 for FRs (p < 0.01). In comparison to other detectors, our detector had a relatively higher sensitivity and specificity. In conclusion, our automated detector is able to accurately calculate a dynamic iEEG baseline in different HFO activity channels using the maximum distributed peak points method, resulting in higher sensitivity and specificity than other available HFO detectors.

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出版当年[2017]版:
大类 | 1 区 工程技术
小类 | 1 区 计算机:人工智能
最新[2023]版:
大类 | 2 区 计算机科学
小类 | 2 区 计算机:人工智能
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出版当年[2016]版:
Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE
最新[2023]版:
Q1 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者机构: [1]Neuroelectrophysiological Laboratory Xuanwu Hospital, Capital Medical University, Beijing, P. R. China [2]Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, P. R. China
通讯作者:
通讯机构: [4]Functional Neurology and Neurosurgery Beijing Haidian Hospital, Beijing, P. R. China [7]Department of Neruology, Beijing Children’s Hospital Capital Medical University, Beijing, P. R. China
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