机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory of Neuromodulation, Beijing, China,[3]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Ministry of Science and Technology, Beijing, China
Objective:Tourette syndrome (TS) is a complicated sensorimotor disorder. Some patients with TS relieve their involuntary premonitory urgesviatics. However, the effect of the motor system on the sensory system has not yet been elucidated. The purpose of the present study was to investigate changes in the excitability of the sensory cortex following repetitive transcranial magnetic stimulation (rTMS) of the motor cortex in patients with TS. Methods:Twenty-nine patients with TS and 20 healthy, age-matched controls were enrolled in this study. All subjects were divided into four groups: patients with rTMS, patients with sham-rTMS, controls with rTMS, and controls with sham-rTMS. The clinical severity of tics was evaluated using the Yale Global Tic Severity Scale. Single somatosensory evoked potentials (SEPs) and paired SEPs were recorded by stimulating the median nerve at the wrist of all subjects. The resting motor threshold (RMT) was tested in each subject in the rTMS group. Afterwards, all four groups were administered rTMS (1 Hz, 90% RMT) or sham-rTMS for 200 s, followed by a 15-min rest. Finally, single SEPs and paired SEPs were repeated for each subject. Results:No significant differences in RMT, the amplitudes of single SEPs, or the suppression of paired SEPs were observed between patients with TS and controls at baseline. After rTMS, a significant suppression of the peak-to-peak amplitude of the N20-P25 responses of single SEPs was observed in both controls (p= 0.049) and patients (p< 0.0001). The suppression of the N20-P25 peak-to-peak amplitude was more significant in patients than in controls (p= 0.039). A significant difference in the suppression of paired SEPs after rTMS was not observed between groups. Conclusions:The more significant suppression of N20-P25 components of single SEPs with normal suppressed paired SEPs in patients with TS after 1-Hz rTMS of the motor cortex suggests that the suppressive effect of the motor system on the sensory system might originate from the motor-sensory cortical circuits rather than the sensory system itself.
基金：
This research was supported by Beijing Key Clinical Specialty
Excellence Project and the National Key Research and
Development Program of China (Grant No. 2016YFF0201002).
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory of Neuromodulation, Beijing, China,[3]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Ministry of Science and Technology, Beijing, China
通讯作者：
推荐引用方式(GB/T 7714)：
Ying Sun,Hua Wei,Yicong Lin,et al.The Suppressive Effect of the Motor System on the Sensory System in Patients With Tourette Syndrome[J].FRONTIERS IN NEUROLOGY.2020,11:doi:10.3389/fneur.2020.00855.
APA：
Ying Sun,Hua Wei,Yicong Lin&Yuping Wang.(2020).The Suppressive Effect of the Motor System on the Sensory System in Patients With Tourette Syndrome.FRONTIERS IN NEUROLOGY,11,
MLA：
Ying Sun,et al."The Suppressive Effect of the Motor System on the Sensory System in Patients With Tourette Syndrome".FRONTIERS IN NEUROLOGY 11.(2020)
