Associations between social and intellectual activities with cognitive trajectories in Chinese middle-aged and older adults: a nationally representative cohort study(Open Access)
机构：[1]Department of Epidemiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.[2]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No. 10 Xitoutiao, You’anmen Wai, Fengtai District, Beijing 100069, China.[3]Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China.[4]Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, New Orleans, Louisiana 70112, USA.[5]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.[6]Department of Health Care Administration, College of Health and Human Services, California State University, Long Beach, 1250 Bellflower Blvd, Long Beach, CA 90840, USA.[7]Center for Evidence-Based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.[8]Department of Mathematics and Statistics, La Trobe University, Melbourne, VIC, Australia.[9]Global Health and Genomics, School of Medical Sciences and Health, Edith Cowan University, Perth, WA 6027, Australia
BACKGROUND: Associations between the frequency of social and intellectual activities and cognitive trajectories are understudied in Chinese middle-aged and older adults. We aimed to examine this association in a nationally representative longitudinal study. METHODS: The China Health and Retirement Longitudinal Study (CHARLS) is a nationally representative sample of Chinese middle-aged and older participants. The frequency of social and intellectual activities was measured at baseline. Interview-based cognitive assessments of orientation and attention, episodic memory, and visuospatial skills and the calculation of combined global scores were assessed every 2 years from 2011 to 2016. Cognitive aging trajectories over time were analyzed using group-based trajectory modeling, and the associations of the trajectory memberships with social and intellectual activities were analyzed using multinomial logistic regression. Odds ratios (OR) and 95% confidence intervals (CI) were reported. RESULTS: Among 8204 participants aged 50-75 years at baseline, trajectory analysis identified three longitudinal patterns of cognitive function based on the global cognitive scores: "persistently low trajectory" (n = 1550, 18.9%), "persistently moderate trajectory" (n = 3194, 38.9%), and "persistently high trajectory" (n = 3460, 42.2%). After adjustment for sociodemographic variables, lifestyles, geriatric symptoms, and health conditions, more frequent intellectual activities (OR 0.54, 95% CI 0.38-0.77) and social activities (OR 0.79, 95% CI 0.65-0.95) were both associated with a lower likelihood of being in the "persistently low trajectory" for global cognitive function. CONCLUSIONS: These findings suggested that more frequent social and intellectual activities were associated with more favorable cognitive aging trajectories.
基金：
National Natural Science Foundation of China
(grant number: 81530087).
第一作者机构：[1]Department of Epidemiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.[2]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No. 10 Xitoutiao, You’anmen Wai, Fengtai District, Beijing 100069, China.[3]Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Haibin Li,Changwei Li,Anxin Wang,et al.Associations between social and intellectual activities with cognitive trajectories in Chinese middle-aged and older adults: a nationally representative cohort study(Open Access)[J].ALZHEIMERS RESEARCH & THERAPY.2020,12(1):doi:10.1186/s13195-020-00691-6.
APA：
Haibin Li,Changwei Li,Anxin Wang,Yanling Qi,Wei Feng...&Xiuhua Guo.(2020).Associations between social and intellectual activities with cognitive trajectories in Chinese middle-aged and older adults: a nationally representative cohort study(Open Access).ALZHEIMERS RESEARCH & THERAPY,12,(1)
MLA：
Haibin Li,et al."Associations between social and intellectual activities with cognitive trajectories in Chinese middle-aged and older adults: a nationally representative cohort study(Open Access)".ALZHEIMERS RESEARCH & THERAPY 12..1(2020)
医学