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Protein quality control of cell stemness

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机构: [1]State Key Laboratory of Membrane Biology, Institute of Zoology, ChineseAcademy of Sciences, Beijing 100101, China [2]University of Chinese Academyof Sciences, Beijing 100049, China [3]China National Center for Bioinformation,Beijing 100101, China [4]CAS Key Laboratory of Genomic and PrecisionMedicine, Collaborative Innovation Center of Genetics and Development,Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101,China [5]Institute for Stem cell and Regeneration, Chinese Academy ofSciences, Beijing 100101, China [6]State Key Laboratory of Stem Cell andReproductive Biology, Institute of Zoology, Chinese Academy of Sciences,Beijing 100101, China [7]Beijing Institute for Brain Disorders, AdvancedInnovation Center for Human Brain Protection, National Clinical ResearchCenter for Geriatric Disorders, Xuanwu Hospital Capital Medical University,Beijing 100053, China
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关键词: Autophagy Chaperones Protein quality control Stem cells Stemness Ubiquitin-proteasome system Unfolded protein response

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Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis. Especially, continued proliferation and differentiation of stem cells require a high rate of translation; therefore, accurate PQC systems are essential to maintain stem cell function. Growing evidence suggested crucial roles of PQC systems in regulating the stemness and differentiation of stem cells. This review focuses on current knowledge regarding the components of the proteostasis network in stem cells, and the importance of proteostasis in maintaining stem cell identity and regenerative functions. A complete understanding of this process might uncover potential applications in aging intervention and aging-related diseases. © 2020, The Author(s).

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第一作者机构: [1]State Key Laboratory of Membrane Biology, Institute of Zoology, ChineseAcademy of Sciences, Beijing 100101, China [2]University of Chinese Academyof Sciences, Beijing 100049, China
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