机构：[1]Institute of Psychology, Chinese Academy of Sciences, Beijing, China,[2]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China,[3]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China,神经科系统神经内科首都医科大学宣武医院[4]Department of Neurology and Neurobiology, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China,神经科系统神经内科首都医科大学宣武医院[5]Institute of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China,[6]Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China
The ability to sequence thoughts and actions is impaired in Parkinson's disease (PD). In PD, a distinct error pattern has been found in the offline performance of sequential working memory. This study examined how PD's performance of sequential working memory unfolds over time using mouse tracking techniques. Non-demented patients with mild PD (N = 40) and healthy controls (N = 40) completed a computerized digit ordering task with a computer mouse. We measured response dynamics in terms of the initiation time, ordering time, movement time, and area under the movement trajectory curve. This approach allowed us to distinguish between the cognitive processes related to sequence processing before the actual movement (initiation time and ordering time) and the execution processes of the actual movement (movement time and area under the curve). PD patients showed longer initiation times, longer movement times, and more constrained movement trajectories than healthy controls. The initiation time and ordering time negatively correlated with the daily exposure to levodopa and D2/3 receptor agonists, respectively. The movement time positively correlated with the severity of motor symptoms. We demonstrated an altered temporal profile of sequential working memory in PD. Stimulating D1 and D2/3 receptors might speed up the maintenance and manipulation of sequences, respectively.
基金：
National Natural Science
Foundation of China (To ZY, 31771216), the Shanghai Municipal
Science and TechnologyMajor Project (To ZY, 2018SHZDZX05),
and the National Key Research and Development Program of
China (To PC, 2018YFC1312001).
第一作者机构：[1]Institute of Psychology, Chinese Academy of Sciences, Beijing, China,[2]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Guanyu,Ma Jinghong,Chan Piu,et al.Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease[J].FRONTIERS IN PSYCHOLOGY.2021,12:doi:10.3389/fpsyg.2021.631672.
APA：
Zhang, Guanyu,Ma, Jinghong,Chan, Piu&Ye, Zheng.(2021).Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease.FRONTIERS IN PSYCHOLOGY,12,
MLA：
Zhang, Guanyu,et al."Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease".FRONTIERS IN PSYCHOLOGY 12.(2021)
