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Wilms’ tumor 1 (Wt1): The vaccine for cancer(Open Access)

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机构： [1]Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA [2]Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA [3]Department of Thoracic Surgery, Xuanwu Hospital Capital Medical University, Beijing, China

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关键词： Cancer medicine Cancer vaccine Clinical trials Immunotherapy Leukemia Peptide-based vaccine Preclinical trails Solid cancer Toxicity WT1 gene

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Vaccines have been used to fight and protect against infectious diseases for centuries. With the emergence of immunotherapy in cancer treatment, researchers began investigating vaccines that could be used against cancer, especially against tumors that are resistant to conservative chemotherapy, surgery, and radiotherapy. The Wilms’ tumor 1 (WT1) protein is immunogenic, has been detected in almost all types of malignancies, and has played a significant role in prognosis and disease monitoring. In this article, we review recent developments in the treatment of various types of cancers with the WT1 cancer vaccine; we also discuss theoretic considerations of various therapeutic approaches, which were based on preclinical and clinical data. © Innovative Healthcare Institute.

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第一作者机构： [1]Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

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