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Exogenous expression of WT1 gene influences U937 cell biological behaviors and activates MAPK and JAK-STAT signaling pathways

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资源类型：

收录情况： ◇ SCIE

作者：
Li, Xiaoyan[1,2,3,4] * ; Li, Yan[1,2,3] ; Yuan, Tian[1,2,3] ; Zhang, Qing[1,2,3] ; Jia, Yujiao[1,2,3] ; Li, Qihui[1,2,3] ; Huai, Lei[1,2,3] ; Yu, Pei[1,2,3] ; Tian, Zheng[1,2,3] ; Tang, Kejing[1,2,3] ; Wang, Min[1,2,3] ; Xing, Haiyan[1,2,3] ; Rao, Qing[1,2,3] ; Mi, Yingchang[1,2,3] ;
机构： [1]Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin, Peoples R China; [2]Chinese Acad Med Sci, Blood Dis Hosp, Tianjin, Peoples R China; [3]Peking Union Med Coll, Tianjin, Peoples R China; [4]Capital Med Univ, Beijing Tiantan Hosp, Dept Hematol, Beijing, Peoples R China
出处：
DOI： 10.1016/j.leukres.2014.05.006
ISSN：

关键词： Wilms' tumor 1 (WT1) gene Leukemia Target gene Signaling pathway Microarraya

摘要：
Wilms' tumor 1 (WT1) gene plays important roles in leukemogenesis. To further explore its underlying mechanisms, we transfected two WT1 isoforms, WT1(+17AA/-KTS) and WT1(+17AA/+KTS) into U937, a WT1-null monoblastic cell line, studied their effects on migration, colony formation, apoptosis, gene expression and pertinent signaling pathways of U937 cells. The results showed that WT1(+17AA/-KTS), but not WT1(+17AA/+KTS), enhanced migration and colony forming abilities of U937 cells, and suppressed etoposide-induced U937 cell apoptosis. Transfection of WT1 isoforms activated gene expressions of chemokine, and induced up-regulation of signaling molecules involved in JAK-STAT and MAPK signaling pathways. This study showed that exogenous expression of WT1 gene remarkably affected biological behaviors of U937 cells, and these effects are possibly mediated by up-regulation of genes related to chemokine, JAK-STAT and MAPK signaling pathways. (C) 2014 Elsevier Ltd. All rights reserved.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30870913]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2013]版：
大类 | 3 区 医学
小类 | 3 区 血液学 3 区 肿瘤学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 血液学 4 区 肿瘤学
JCR分区：
出版当年[2012]版：
Q2 ONCOLOGY Q2 HEMATOLOGY
最新[2023]版：
Q3 ONCOLOGY Q3 HEMATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2012版] 出版当年五年平均 出版前一年[2011版] 出版后一年[2013版]

第一作者：
第一作者机构： [1]Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin, Peoples R China; [2]Chinese Acad Med Sci, Blood Dis Hosp, Tianjin, Peoples R China; [3]Peking Union Med Coll, Tianjin, Peoples R China; [4]Capital Med Univ, Beijing Tiantan Hosp, Dept Hematol, Beijing, Peoples R China
通讯作者：
通讯机构： [1]Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin, Peoples R China; [2]Chinese Acad Med Sci, Blood Dis Hosp, Tianjin, Peoples R China; [3]Peking Union Med Coll, Tianjin, Peoples R China;
推荐引用方式(GB/T 7714)：
Li Xiaoyan,Li Yan,Yuan Tian,et al.Exogenous expression of WT1 gene influences U937 cell biological behaviors and activates MAPK and JAK-STAT signaling pathways[J].LEUKEMIA RESEARCH.2014,38(8):931-939.doi:10.1016/j.leukres.2014.05.006.
APA：
Li, Xiaoyan,Li, Yan,Yuan, Tian,Zhang, Qing,Jia, Yujiao...&Mi, Yingchang.(2014).Exogenous expression of WT1 gene influences U937 cell biological behaviors and activates MAPK and JAK-STAT signaling pathways.LEUKEMIA RESEARCH,38,(8)
MLA：
Li, Xiaoyan,et al."Exogenous expression of WT1 gene influences U937 cell biological behaviors and activates MAPK and JAK-STAT signaling pathways".LEUKEMIA RESEARCH 38..8(2014):931-939

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